Can I quit Prolia shots after taking five shots without problems?

Posted by wnk @wnk, May 20 3:39pm

May I quit taking Prolia shots after taking five shots without having rebound problems? I had a Dexa October 9, 2023 and the bone mineral density for my left femur was 0.631 gm/cm sq. with a T-score of -2.0 which was an improved bone density by 4.4% from the prior study. My lumbar spine (L1-L4) had a bone mineral density of 0.840 gm/cm sq. with a T-score of -1.9 which was an improved bone density of 10.8% compared to the prior study. A doctor told me I could just quit the Prolia shot without any other treatment but I am concerned about the "rebound problem" that I have been reading about. Thanks for any response.

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@wnk are you seeing an endocrinologist? If it were me, I would talk to a doctor about taking a bisphosphonate- Reclast or alendronate- to combat any possible rebound. Every study I have seen recommends that as does my doctor for patients stopping Prolia, even after 4 or 5 shots. Hoping someone else chimes in here who has actually done this course of Prolia.

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@windyshores

@wnk are you seeing an endocrinologist? If it were me, I would talk to a doctor about taking a bisphosphonate- Reclast or alendronate- to combat any possible rebound. Every study I have seen recommends that as does my doctor for patients stopping Prolia, even after 4 or 5 shots. Hoping someone else chimes in here who has actually done this course of Prolia.

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I have read that 1 injection of Prolia and stopping with out a bisphosphonate won’t cause the rebound, probably.
But anymore than 1 will. I think your doctor is wrong.

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@windyshores

@wnk are you seeing an endocrinologist? If it were me, I would talk to a doctor about taking a bisphosphonate- Reclast or alendronate- to combat any possible rebound. Every study I have seen recommends that as does my doctor for patients stopping Prolia, even after 4 or 5 shots. Hoping someone else chimes in here who has actually done this course of Prolia.

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I have been on a number of osteoporosis meds including, fosamax, Bonita, Forteo, recast and most recently prolia. I had 4 shots of prolia. Just prior to my shot in November, I had a stress fracture in my left foot. I was supposed to have another shot of prolia and I recently had a femur break. I cancelled that shot. My endocrinologist is not suggesting evenly as she said there is not enough evidence that it would be helpful to someone who has had a bone break. I think she is leaning toward Forteo. When I took this drug, about 10 years ago, (for 2 years), the literature indicated you can only take Forteo for 2 years in your lifetime. I tried researching, and have not found any current protocols. The issue with stopping prolia is that you are subject to spinal fractures.

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I thought that Forteo and Tymlos did not work to stop bone loss after Prolia. You are in a bind because you have done bisphosphonates already. Both Prolia and bisphosphonates are anti-resorptives and the effect of those (atypical fractures) can occur if taken too long.

Someone posted a video with Dr. Paul Miller the other day where a bunch of endos discuss meds and they said that preliminary studies show that Evenity can stop Prolia rebound. Personally I would try to convince the doctor to try Evenity- or find another doctor. It would seem, from what I have read and been told, that you don't have any other good options.

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Do you you have any specialists you could see, like a rheumatologist or endocrinologist ? Also, do a lot of research on the internet at reliable sites.

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@windyshores

I thought that Forteo and Tymlos did not work to stop bone loss after Prolia. You are in a bind because you have done bisphosphonates already. Both Prolia and bisphosphonates are anti-resorptives and the effect of those (atypical fractures) can occur if taken too long.

Someone posted a video with Dr. Paul Miller the other day where a bunch of endos discuss meds and they said that preliminary studies show that Evenity can stop Prolia rebound. Personally I would try to convince the doctor to try Evenity- or find another doctor. It would seem, from what I have read and been told, that you don't have any other good options.

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Can you re-post the video with Dr Paul Miller. Would appreciate it.

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@ems926

Can you re-post the video with Dr Paul Miller. Would appreciate it.

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@ems926 watch Dr. Ben Leder's video on YouTube entitled "Combinations and Sequencing Approaches to Osteoporosis." I don't have the link to Miller anymore.

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@windyshores

@ems926 watch Dr. Ben Leder's video on YouTube entitled "Combinations and Sequencing Approaches to Osteoporosis." I don't have the link to Miller anymore.

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Thank you so much

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