Can Gabapentin make neuropathy pain worse?

Posted by cwallen9 @cwallen9, Apr 16, 2019

I started getting peripheral neuropathy pain about nine months ago in my feet and hands right after I received a cervical steroid injection. I started taking gabapentin about 7 months ago. I have gradually increased my dose from 100 mg a day to 1500 mg. I can't say that it has decreased my pain at all. In fact, my pain has gotten steadily worse. I was just wondering if it is possible that gabapentin can sometimes make neuropathy pain worse. My EMG and biopsy results are negative for short fiber neuropathy so far.

Liked by Dee, Leonard

@cwalkowicz

It does not sound like you have neuropathy but rather a pinched nerve. I was told I had nonspecific neuropathy but when tests were done I had two pinched nerves, a herniated disc, an annular tear and Radiculopathy. I would see a spine doctor before things get very bad. I waited too long and the pain became unbearable.

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I have pinched nerve, herniated disc and radiculopathy and Igg vs Fgfr3 10.000 Does it mean fgfr3 refers to radiculopathy or I have radiculopathy on top of neuropathy?
I had very bad shingle too few months back and some neuromuscular website suggests Fgfr3 is an indicator for localized neuropathy due to shingles

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hi
I've had shingles and it can be rough. I had and have herniated disks in my lower back and neck. The pain is much different then the neuropathy I have. The shooting pain the cold feet the burning in my feet and the way my legs always feel beat up is what I feel from neuropathy. What you feel from a pinched nerve is normally localized to one leg or arm not both like neuropathy. The pain is definitely different. The burning or cramping caused by a pinched nerve doesn't make your feet cold make your feet and hands burn in the same way. It doesn't dramatically cause you to loose all coordination and affect your ability to concentrate. When I was hit with neuropathy I described it to my doctor like this my legs are killing me my feet are cold yet they burn my hands are the same but to a lees extent. I have shooting pain that's like something is drilling into my legs I fall and loose my balance all the time and all the sudden I've become stupid. Much different from my pinched nerves.
Hope this helps

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@adamek3638

I have pinched nerve, herniated disc and radiculopathy and Igg vs Fgfr3 10.000 Does it mean fgfr3 refers to radiculopathy or I have radiculopathy on top of neuropathy?
I had very bad shingle too few months back and some neuromuscular website suggests Fgfr3 is an indicator for localized neuropathy due to shingles

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@adamek3638, I found a few articles that may provide some more information for you.

FGFR3 Gene: https://ghr.nlm.nih.gov/gene/FGFR3
FGFR3 Antibodies in Neuropathy. What to do with them?: https://n.neurology.org/content/90/15_Supplement/P1.463
Clinical Characterisation of Sensory Neuropathy With anti-FGFR3 Autoantibodies: https://pubmed.ncbi.nlm.nih.gov/31690697/

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@da20pilot

hi
I've had shingles and it can be rough. I had and have herniated disks in my lower back and neck. The pain is much different then the neuropathy I have. The shooting pain the cold feet the burning in my feet and the way my legs always feel beat up is what I feel from neuropathy. What you feel from a pinched nerve is normally localized to one leg or arm not both like neuropathy. The pain is definitely different. The burning or cramping caused by a pinched nerve doesn't make your feet cold make your feet and hands burn in the same way. It doesn't dramatically cause you to loose all coordination and affect your ability to concentrate. When I was hit with neuropathy I described it to my doctor like this my legs are killing me my feet are cold yet they burn my hands are the same but to a lees extent. I have shooting pain that's like something is drilling into my legs I fall and loose my balance all the time and all the sudden I've become stupid. Much different from my pinched nerves.
Hope this helps

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This description is the same as what I have experienced. It is quite accurate, in my view. Therapy can work for pinched nerves if you do it long enough. I am still puzzled about neuropathy. Doris Huffman

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@da20pilot

hi
I've had shingles and it can be rough. I had and have herniated disks in my lower back and neck. The pain is much different then the neuropathy I have. The shooting pain the cold feet the burning in my feet and the way my legs always feel beat up is what I feel from neuropathy. What you feel from a pinched nerve is normally localized to one leg or arm not both like neuropathy. The pain is definitely different. The burning or cramping caused by a pinched nerve doesn't make your feet cold make your feet and hands burn in the same way. It doesn't dramatically cause you to loose all coordination and affect your ability to concentrate. When I was hit with neuropathy I described it to my doctor like this my legs are killing me my feet are cold yet they burn my hands are the same but to a lees extent. I have shooting pain that's like something is drilling into my legs I fall and loose my balance all the time and all the sudden I've become stupid. Much different from my pinched nerves.
Hope this helps

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Very accurate. I have cervical neuralgia, it feels like something is crushing my head. And TMJ. I have problems with balance as well

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This topic, like the other topic about gabapentin, has the hallmarks of an organized "smear campaign". Peggy

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@pfbacon

This topic, like the other topic about gabapentin, has the hallmarks of an organized "smear campaign". Peggy

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I am willing to share my experiences in relieving pain in my old age, but I do not participate in organized "smear campaigns." I am not a medical person or a group organizer for any cause. I only share my experiences, and have not been successful personally with gabapentin. I read and study about medicines to protect my health. I know the difference between opinions and facts, and I am not easily swept into a certain view. In this time of isolation, I prefer to not discuss health issues if someone accuses me negatively. Dorisena

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@adamek3638

Very accurate. I have cervical neuralgia, it feels like something is crushing my head. And TMJ. I have problems with balance as well

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I have it too – cervical neuralgia and tmj, which makes me think the root of the problem is cervical misalignment. However I had negative experience with chiropractor who manually tried to fix my spine and I ended up with pinched nerve. Attending physical therapy since couple of months now. Does anyone try alpha lipoic acid? I also got dulsevia

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@pfbacon

This topic, like the other topic about gabapentin, has the hallmarks of an organized "smear campaign". Peggy

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smear campaign? Everyone reacts differently to medications. Chill out and let everyone share their experience

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@adamek3638

smear campaign? Everyone reacts differently to medications. Chill out and let everyone share their experience

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Thanks, Kathy. I won't have much time for sharing now because I will begin my planting this week. I can only do a little at a time, but I can still get out there. Dorisena

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@adamek3638

I have it too – cervical neuralgia and tmj, which makes me think the root of the problem is cervical misalignment. However I had negative experience with chiropractor who manually tried to fix my spine and I ended up with pinched nerve. Attending physical therapy since couple of months now. Does anyone try alpha lipoic acid? I also got dulsevia

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Hello @adamek3638. Im sorry you had a negative experience with your chiropractor. I understand and was originally diagnosed with cervical neuralgia. I'm blessed to only get a nasty TMJ bout once or twice a year. In my earlier stages, before my neuropathy diagnosis, I was in PT, tried acupuncture and a chiropractor. The chiropractor used this clicker device from neck down spine and hurt me. Each visit he adjusted until we got down to a "child setting". Didn't matter…still hurt and provoked migraine. It was not the right treatment for me. As far as alpha lipoic acid …yes, I have taken it along with Acetyl L Carnitine as part of my neuropathy supplement protocol. I believe in it. I sure hope PT brings you some relief. Best of luck to you.
Rachel

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@rwinney

Hello @adamek3638. Im sorry you had a negative experience with your chiropractor. I understand and was originally diagnosed with cervical neuralgia. I'm blessed to only get a nasty TMJ bout once or twice a year. In my earlier stages, before my neuropathy diagnosis, I was in PT, tried acupuncture and a chiropractor. The chiropractor used this clicker device from neck down spine and hurt me. Each visit he adjusted until we got down to a "child setting". Didn't matter…still hurt and provoked migraine. It was not the right treatment for me. As far as alpha lipoic acid …yes, I have taken it along with Acetyl L Carnitine as part of my neuropathy supplement protocol. I believe in it. I sure hope PT brings you some relief. Best of luck to you.
Rachel

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Have you asked a doctor about trigeminal neuralgia? It is the most painful thing I have ever experienced, but I use pressure if it happens a couple of times a year, and I don't go for the medicine, or I may not be able to get out of bed. Years ago when I had TMJ my dentist worked on my bite and I taught myself to sleep with my tongue slightly between my teeth and the problem went away. I also never sit slumped with my chin leaning in my hand, as the chiropractor said that could make pain. Yes, as I mentioned before, I had a pinched nerve in the upper spine which took months of therapy to loosen. I did stretching exercises for a couple of years and developed a very nice straight back in my younger days. I still work on it all, as I never found the magic cure. And my spine has shrunk, of course.
My chiropractor says he can't do much for this old body now, so I do some stretching at home. I am getting by pretty well. Dorisena

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@dorisena

This description is the same as what I have experienced. It is quite accurate, in my view. Therapy can work for pinched nerves if you do it long enough. I am still puzzled about neuropathy. Doris Huffman

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I can still remember how and when I got the pinched nerve, but since I knew nothing about the problem, it took a while for the doctor to send me to the therapist. He just prescribed pain pills which did nothing. I pulled a bushel of tomatoes through the garden, bent over, and it was very heavy. I was also sewing a project and I spent long periods bent over the machine. When I leaned back in the sink at the beauty salon to wash my hair, it pinched and I let it go, going out of town to a convention. I went to the University hospital there and after X-ray was told to go home in a hurry because I had big problems. I laid on the floor at the airport waiting on my flight. The local doctor said I didn't need surgery. Period. Then the battle began. Three months later he finally sent me to a therapist who was trained in Europe and America. It took months of therapy, which cost me plenty, to get the pain to stop, and I continued the exercises for a couple of years after that because I was so afraid in the garden. I threw my bushel baskets away. They showed me with a model how the nerve got pinched by the wrong positions, and how it opens with the therapeutic positions. This is much different than neuropathy from my lower spine conditions. However, in both cases pain medication did not help, but injections helped with the lower spine before surgery.
It is a good thing there was no gun in the house………My Chiropractor has been my best therapist. That's all I really know about such matters. Even a stiff drink, which I do not like, does not slow down the pain when it comes. I am pain free now but can't walk far at a time. My muscles are wasted from resting instead of doing more therapy. I do not use a walker. My balance is slowly improving enough that I can garden while leaning on my hoe or shovel. My feet are always cold, so I wear socks to bed. I don't have any answers for others, but believe sharing my experiences might present a clue to less pain. Keep moving and don't quit. Dorisena

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@dorisena

I can still remember how and when I got the pinched nerve, but since I knew nothing about the problem, it took a while for the doctor to send me to the therapist. He just prescribed pain pills which did nothing. I pulled a bushel of tomatoes through the garden, bent over, and it was very heavy. I was also sewing a project and I spent long periods bent over the machine. When I leaned back in the sink at the beauty salon to wash my hair, it pinched and I let it go, going out of town to a convention. I went to the University hospital there and after X-ray was told to go home in a hurry because I had big problems. I laid on the floor at the airport waiting on my flight. The local doctor said I didn't need surgery. Period. Then the battle began. Three months later he finally sent me to a therapist who was trained in Europe and America. It took months of therapy, which cost me plenty, to get the pain to stop, and I continued the exercises for a couple of years after that because I was so afraid in the garden. I threw my bushel baskets away. They showed me with a model how the nerve got pinched by the wrong positions, and how it opens with the therapeutic positions. This is much different than neuropathy from my lower spine conditions. However, in both cases pain medication did not help, but injections helped with the lower spine before surgery.
It is a good thing there was no gun in the house………My Chiropractor has been my best therapist. That's all I really know about such matters. Even a stiff drink, which I do not like, does not slow down the pain when it comes. I am pain free now but can't walk far at a time. My muscles are wasted from resting instead of doing more therapy. I do not use a walker. My balance is slowly improving enough that I can garden while leaning on my hoe or shovel. My feet are always cold, so I wear socks to bed. I don't have any answers for others, but believe sharing my experiences might present a clue to less pain. Keep moving and don't quit. Dorisena

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Have you try dry needling? I had terrible muscles problems, they were stiff and pressing on my discs. My physiotherapist and hollistic dr are my best friends now too.. I suffered from HPA Axis disfigures as well and adrenal fatigue. Apparently the same drugs used for neuropathy- help for HPA Axis. Been through a lot, happy to share my experience if anyone could benefit from it.

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@mictim

Lisa,

For myself Gabapentin made my PN worse and made my arms jump and twitch basically controllable, as soon as I quite taking it that was gone.

I can see where some people would benefit from Gabapentin or Pregablin (Lyrica types), but it is not for me.

I do feel that Pharma and the medical community really needs to look at less use of single molecule (man made) internal drug therapy of treating PN, as people are getting tired of treating only symptoms of PN. It maybe that possibly incorporating some of the eastern primary as an more interrogative approach maybe a benefit. Less Opiates (new FDA rules) is good, but at least give us a quality replacement for PN. PN is within the reachable sub-dermal regions even in the feet (dead skin layers) therefore a topical pain relief treatment approach should be very beneficial for people with PN, at least that is my view after living with PN for ~15 years.

Off my soap box, the answer for myself is Gabapentin and Pregablin (Lyrica) simply made things far worse, as it seem to affect the whole CNS and not the PN issue.

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I to believe that gabapentin is making my PN worse. What I've experienced in the 1 month since i started Gabapentin was that the PN pain – my feet are hot and feel like the skin has shrunk. Thay also feel heavy. My doctor has been increasing the dose from 100/300/300 morning/noon/bedtime to 600/600/600. On all these dosages, the pain begins around noon and continues until to fall asleep with it. When I awake 8 hrs later there is not pain! This pattern has continued since I started on Gaba. To me that says Gaba is causing the pain. My doctor started me on Gaba because I has an impacted nerve at L5/S1. I was fortunate to have surgery on March 30, 2020 that solved that problem. However because the impacted nerver will take at least another month to heal I was told to stay on the Gapabentin for the pain. Prior to the surgery I had a nerve conduction velocity test that showed I had mild PN in both legs and feet. But the pain I feel is anything but mild. Does anyone else who takes Gabapentin have symptoms like mine? Does PN pain disappear during sleep and come back during the day?

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