Can anyone share their experience with Dutasteride (Avodart)?

Posted by joe1 @joe1, May 21, 2024

Hi,

I'm 63 and have BPH and prostate cancer. The urologist told be not to worry about the cancer (Gleason 3 +3 = 6) and gave me Dutasteride (aka: Avodart) for the BPH. My prostate is large (62 CC) and I pee 3 times per night with some restriction in the flow. I haven't started Dutasteride because I'm concerned about the side effects (mainly developing aggressive cancer, sexual problem, and man-breasts).

Can anyone share their experiences with Dutasteride (good or bad) and specifically regarding these side effects? I have bad luck with side effects and don't want to make things worse.

Thanks
Joe

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Hi. FYI. I just posted a response to your post.

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Profile picture for ace09 @ace09

Well , I've been on it for less than a year. I had a hernia operation and I thought I had a significant side effect from that which I brought up with my urologist just yesterday. Who proceeded to inform.me that what I had experienced was a known side effect from the Dutasreride.
Some time ago. I noticed that my erect penis was not as big as I was used to.( Normally my solid erection. Pressed against my cell phone showed about 1/4" above the top of my phone) it was at least 1/4" BELOW the edge of my phone! So at least 1/2 " shorter! So I took a good look at my non erect penis ( flaccid)that too was smaller! In fact almost child like.!
The urination problem has certainly improved with the medication. But it certainly is a significant side effect. My Dr explained that the drug causes the prostate tissue d ur to shrink ..and also the penis..soft & hard! Somewhat embarrassing in a public shower situation.
I don't have a partner..but nevertheless I still indulge in and enjoy masturbation..and I do miss the length and girth of my normal penis. I also notice that erections are not so easy to stimulate and are less solid in nature..less firm!
Unfortunatly I think i have to accept it but I had a 6.5 " erection it is less than 6" about 5.5" now..I hope it does not continue to shrink.

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I was prescribed Dutasteride six months ago as a preventative as I was diagnosed with a slightly enlarged prostate.
I found this forum as I was researching for any side effects reported. I am trying to identify if this is drug is causing me some issues.
I have been experiencing cold and numb feet and toes. Slight swelling from my knees to my ankles. Breathlessness and dizziness on slight exertion. Also loss of sexual drive, poor erections and shrinking of my penis. . I have had extensive ultra sound tests for PAD and Artirial Stonosis which came back negative which leads me to think that Dutasteride may be the issue. I am taking other medication, Statin and BP tablets and trying to determine what may be causing these symptons.

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Profile picture for graysilk @graysilk

I was prescribed Dutasteride six months ago as a preventative as I was diagnosed with a slightly enlarged prostate.
I found this forum as I was researching for any side effects reported. I am trying to identify if this is drug is causing me some issues.
I have been experiencing cold and numb feet and toes. Slight swelling from my knees to my ankles. Breathlessness and dizziness on slight exertion. Also loss of sexual drive, poor erections and shrinking of my penis. . I have had extensive ultra sound tests for PAD and Artirial Stonosis which came back negative which leads me to think that Dutasteride may be the issue. I am taking other medication, Statin and BP tablets and trying to determine what may be causing these symptons.

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@graysilk I have been on it for 3+ years. The officially listed common side effects include
• Decreased libido (sex drive)
• Erectile dysfunction
• Reduced semen volume or ejaculation disorders
• Breast tenderness or enlargement (gynecomastia)
• Dizziness or lightheadedness

When my Urologiat prescribed it he also warned that should I have undetectable (at the time) or new prostate cancer that had been correlated with more aggressive forms of the cancer.

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68, I had a manual exam , he found something and immediately put me on Dutasteride ( I was going a few times at night) .. after 2 weeks to get an MRI and 2 weeks wait for result , I was relieved that he didn't see anything of concern ... almost immediately after starting dutasteride -if I did something a bit strenuous like walking up a hill ,I would get chest pain more like the worst heartburn of all time -though I wouldn't know ... THIS had never ever happened before - always kept in shape and exercised - my Urologists office NEVER returned my calls even after leaving detailed message ..it was shocking .. then it was obvious that it had shrunk my unit too after about 6 months , and in the meantime my regular Dr. told me " get off of it Now !" .. yes - after further idiocy I just quit that urologist .. , but I quit Dutas Nov 4 /25 and Mar 12/26 ,I'm still getting chest pain , although some days I don't ... Anyone have ANY info on this ?

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I've been on Disasteride for BPH for a little over 3 months. No obvious side effects. No real change in nighttime urination, still 2-3 times per night. Was just noticing the other days that my moobs may have gotten a bit larger, [gynecomastia]. I got off of a water pill spironolactone for that reason; at least I thought that there was a connection. I was also prescribed low dose 5mg Tadalafil aka Cialis. If there is more action in the next month I will ask to be taken off of the Disasteride. Was told I might need to have my plumbing roto-rootered if the Disasteride doesn't help. My big issue

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Profile picture for bodean @bodean

68, I had a manual exam , he found something and immediately put me on Dutasteride ( I was going a few times at night) .. after 2 weeks to get an MRI and 2 weeks wait for result , I was relieved that he didn't see anything of concern ... almost immediately after starting dutasteride -if I did something a bit strenuous like walking up a hill ,I would get chest pain more like the worst heartburn of all time -though I wouldn't know ... THIS had never ever happened before - always kept in shape and exercised - my Urologists office NEVER returned my calls even after leaving detailed message ..it was shocking .. then it was obvious that it had shrunk my unit too after about 6 months , and in the meantime my regular Dr. told me " get off of it Now !" .. yes - after further idiocy I just quit that urologist .. , but I quit Dutas Nov 4 /25 and Mar 12/26 ,I'm still getting chest pain , although some days I don't ... Anyone have ANY info on this ?

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@bodean
I've been on Dutasteride for a while now and don't really know if it is helping or not. Can still pee with no problem but last cystoscopy showed a real garden in the bladder and prostate still expanding. Am thinking about Rezum but haven't talked to the surgeon yet as to whether it is a long term solution for stopping the prostate from continued expansion or a short term solution. I would like to hear from anyone who did the Rezum and what their opinion is on it's efficacy.

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