CA 27-29 numbers rising: Does anyone else have an issue like this?

Posted by sandyjr @sandyjr, Jul 1, 2019

My Ca 27.29 seems to be high....in the 40’s....and my oncologist says that that is probably normal for me. He checked the records from my first bc. Does anyone else have an issue like this?

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I'm posting this list of tumor markers from the gov't. website. For some reason it doesn't list the CA 27-29 which many of our oncologists have done so might need updating. I read, in a British newspaper, that some British doctors are having the CEA done but am not familiar with it.

Have any of you had the Estrogen Receptot Assay done which purportedly tests how well anti-estrogen therapy will work for estrogen positive breast cancer?
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Tumor Markers (excerpt)

CA 15-3 (Cancer Antigen 15-3)
Elevated in 76%
of metastatic breast cancers.

CA-125 (Cancer Antigen-125)
A tumor marker useful for monitoring for ovarian cancer by measuring an antigen to epithelial neoplasms circulating in blood serum. Normal range: 0 - 35 U/mL. Normal range may vary somewhat according to institutional experience. Levels above 35 suggest the presence of ovarian tumor.

CEA (Carcinoembryonic Antigen)
A blood test measuring the presence of an antigen in malignancies arising in entodermal (embryonic) or gastrointestinal tissue. Persistent elevated levels indicate residual or recurrent metastatic carcinoma. CEA assay is nonspecific for identifying a primary site, but it does indicate the presence of malignancy. Smokers may have an elevated CEA without malignant disease.

Estrogen Receptor Assay (ERA)
A laboratory test of breast cancer tissue to determine the responsiveness of the tumor to endocrine therapy or to removal of the ovaries.

https://training.seer.cancer.gov/diagnostic/markers.html
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@callalloo

I'm posting this list of tumor markers from the gov't. website. For some reason it doesn't list the CA 27-29 which many of our oncologists have done so might need updating. I read, in a British newspaper, that some British doctors are having the CEA done but am not familiar with it.

Have any of you had the Estrogen Receptot Assay done which purportedly tests how well anti-estrogen therapy will work for estrogen positive breast cancer?
******************
Tumor Markers (excerpt)

CA 15-3 (Cancer Antigen 15-3)
Elevated in 76%
of metastatic breast cancers.

CA-125 (Cancer Antigen-125)
A tumor marker useful for monitoring for ovarian cancer by measuring an antigen to epithelial neoplasms circulating in blood serum. Normal range: 0 - 35 U/mL. Normal range may vary somewhat according to institutional experience. Levels above 35 suggest the presence of ovarian tumor.

CEA (Carcinoembryonic Antigen)
A blood test measuring the presence of an antigen in malignancies arising in entodermal (embryonic) or gastrointestinal tissue. Persistent elevated levels indicate residual or recurrent metastatic carcinoma. CEA assay is nonspecific for identifying a primary site, but it does indicate the presence of malignancy. Smokers may have an elevated CEA without malignant disease.

Estrogen Receptor Assay (ERA)
A laboratory test of breast cancer tissue to determine the responsiveness of the tumor to endocrine therapy or to removal of the ovaries.

https://training.seer.cancer.gov/diagnostic/markers.html

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Callillo
Thank you for the post .As
always it is very informative and interesting .
After my bilateral lumpectomy last year I have had 2 MRI and Mammogram screening done. Even though the result was satisfactory, I was questioning 2 oncologists about the marker tests.
Either based on their medical practice, or because the government’s protocol/ restriction, both doctors didn’t recommend it.
My concern is -how effective the Tamoxifen or the others (hormone therapy) treatments in preventing cancer returns vs. the drugs side effects.
Even the marker wouldn’t be in the accessible limit , is the medical society can offer the better treatment for the cancer returns prevention.?

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@dianemh

My last CA 27-29 was 625 and they still can’t find any new cancer so not sure how great a test this is

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What additional tests were you given?

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@mamabea

I had a normal mammogram, normal blood work and 48.5 CA 27.29. What can medicine do if it's cancer?

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Had pet scan, cancer cell search, bone scan, brain MRI and CT chest and abdomen

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@mamabea

I had a normal mammogram, normal blood work and 48.5 CA 27.29. What can medicine do if it's cancer?

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I have or they told me I have node recurring breast cancer but ca27/29 is 9...!!!!

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@mamabea

I had a normal mammogram, normal blood work and 48.5 CA 27.29. What can medicine do if it's cancer?

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The tumor marker test is imperfect in that markers things other than cancers can cause the number to rise and not all cancers trigger an increase. Some doctors don't have them done at all because of that though mine includes them because a rise in the result can merit attention. But as @dianemh can testify, finding the reason for the rising number isn't always clear either.

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@mamabea

I had a normal mammogram, normal blood work and 48.5 CA 27.29. What can medicine do if it's cancer?

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Did they find anything?

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@mamabea

Did they find anything?

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No. At least nothing new and the tumors I do have are not growing. It has been steadily going up for the past year from 71 last July to 625 at my last check.

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@dianemh

No. At least nothing new and the tumors I do have are not growing. It has been steadily going up for the past year from 71 last July to 625 at my last check.

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Yay for tumors not growing!
How do they detect tumor growth?

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@dianemh

No. At least nothing new and the tumors I do have are not growing. It has been steadily going up for the past year from 71 last July to 625 at my last check.

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Well, I like it when doctors don't find anything. But do they have any explanations? A cardiologist once told me that dieting (any radical change in food consumption) can increase inflammation in the body and tumor markers can respond to inflammation.

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