CA 27-29 numbers rising: Does anyone else have an issue like this?

My oncologist and I agree that many factors can elevate our CA27-29 numbers, even what we’ve eaten and certain physical activity that took place the days prior to the test.

Therefore, we decided together to discontinue having this test done, and, instead, rely on my bloodwork, physical exams and yearly mammograms.

My oncologist felt the tumor marker was most helpful for those with late stage breast cancer so that they can monitor the effectiveness of treatment lines. ♥️

yes always at same lab.
There is a stable 2 mm linear density in the medial right lower lobe on series 5
image 163. The branching and nodular densities in both lower lobes are again noted
with very much a similar configuration best seen for example on series 5 image 316.
This is associated with several very tiny nodules on the order of 1 to 2 mm. Suspect
benign finding but follow-up is recommended. Suggest 6-month chest CT follow-up. Thought maybe this was from Covid. This was my follow-up. Covid a year ago.
I have another CT end of November.
Just some weird stuff going on, Superficial DVT left arm with phlebitis x 3 (side of BC), severe hot flashes which I never had. I know lymphoedema can occur at any point but never an issue before. Left arm stays swollen with lymph node pain, but ultrasound was negative. Grrr just frustrating!

That is not a big jump and still under 38 so in the normal range. Good to keep watching and asking questions!

How reliable is CA 27.29 TOSOH cancer marker test for HER2+ Metastatic breast cancer reoccurrence? My latest test now is at 35.9. Is there a better test to detect a reoccurrence? I was at a 24 but it has been increasing significantly last 6 months.

When were you 24?

Hello,
there's a detailed discussion about CA 27.29 markers at: https://connect.mayoclinic.org/discussion/ca-27-29-consistently-high-in-the-40s/

Not specific to HER2 +, but some doctors check it and some do not. Mine said she will check it (I have metastatic BC) but it's the scans that she focuses on. There are reports that stress, inflammation, diet changes, etc. might cause some spikes.

Thank you. I will check the site. I have not changed my diet but will check to see what this site has to say.

Before my surgery I did a long list blood test. The nurse took 20 vials.

Here some of my results:

% CD3+CD25+ Lymphs ( 34.8 high reference interval 4.9-25.9)
Circulating tumor cell is 0 ( CTC per 7.5 mL of whole blood)
CA 125 ( 5.2 U/ml)
CA 27-29 (7 U/ml)
CA 15 -3 (8.2 U/ml)
CEA ( 1.1 )
Factor VIII Activity ( 185 high reference interval 56 - 140)
Vitamin D, 25-Hydroxy (24.1 Low ng/mL reference interval 30.0-100.0)

Do you have know what means CD3 and CD25?

My last one was 764! All scans and blood work good so not sure what this test actually shows. Hang in there