CA-125 Results Went Up: Should I be concerned?

Posted by stparker54 @stparker54, Aug 26, 2020

The results of my CA-125 tumor marker test increased from 16.8 to 20.3. This is the fourth time I've had a tumor marker test and it's the first time there was an increase in the results. How concerned should I be?

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smalayman4016 | @smalayman4016 | Mar 31, 2023

My wife’s doctor watches her CA-125 closely and adjusts her chemo based on this and her scans and other tests. I would suggest discussing this with your oncologist.

1morgan | @1morgan | Mar 19, 2023

In reply to @1morgan "That sound great. I am freaking out and hoped I can calm my mind but its..." + (show)

Sorry wrong reply I am also hope and praying for everyone god bless

1morgan | @1morgan | Mar 19, 2023

In reply to @katycot "It is normal to worry a little when this happens. If you don’t have any symptoms,..." + (show)

That sound great. I am freaking out and hoped I can calm my mind but its so hard.
Thank you for your advice

1morgan | @1morgan | Mar 18, 2023

In reply to @colleenyoung "Hi @1morgan, welcome. I moved your question about rising levels of CA 125 to this existing..." + (show)

I see her on Monday I hope to have soon news of what my next step is.

Carrie | @katycot | Mar 18, 2023

It is normal to worry a little when this happens. If you don’t have any symptoms, and it’s only a small blip up perhaps hold your breath and wait for the next test and hopefully it will be back down to the lower level again. Many things can cause some inflammation which result in a brief uptick.

Colleen Young, Connect Director | @colleenyoung | Mar 17, 2023

In reply to @1morgan "two years ago was diagnosed with stage 4 ovarian cancer, went through surgery and then Chemo..." + (show)

Hi @1morgan, welcome. I moved your question about rising levels of CA 125 to this existing discussion:
- - CA-125 Results Went Up: Should I be concerned? https://connect.mayoclinic.org/discussion/ca-125-results-rose/

I did this so you can read previous posts and connect with members like @stparker54 @starko @miriam57 @odette @carole2022 @cctoo @smalayman4016 @drterry @egins1208 @chrissiebee and others.

From Mayo Clinic:
"Rising CA 125 levels MAY indicate that ovarian cancer has come back after treatment. Regular monitoring of CA 125 has NOT been shown to improve outcomes for those with ovarian cancer and may lead to additional and unnecessary rounds of chemotherapy or other treatments."

Usually further testing and monitoring are necessary to confirm what is going on. Has your oncologist suggested further testing?

1morgan | @1morgan | Mar 17, 2023

two years ago was diagnosed with stage 4 ovarian cancer, went through surgery and then Chemo its been a year and 4month in remission. In Feb my CA 125 was 13.5 in March first week my numbers went up to 723. CT shows no signs of anything two weeks later my CA 773. Should I wait for signs or get a PET done? My doctor says we might just be treating a number.
any insite on this would be grateful

chrissiebee | @chrissiebee | Mar 13, 2023

In reply to @drterry "Oh my, I’m so sorry. Urachal Adenocarcinoma is from failure of the bladder to separate from..." + (show)

Thank you for your prayers. My best to you.

drterry | @drterry | Mar 13, 2023

In reply to @chrissiebee "I have a rare bladder cancer also, high grade, but didn't invade the muscle. What treatment..." + (show)

Oh my, I’m so sorry. Urachal Adenocarcinoma is from failure of the bladder to separate from umbilical cord in third trimester in utero. The tumor grew in a diverticulum. I just had surgery to remove the tumor and urachal tracts. There is no protocol its so rare. Praying for you. 🙏🏻🙏🏻🙏🏻