1. < Prostate Cancer
Profile picture for copyman

Anyone have HDR Brachytherapy and Proton beam therapy combo?

Posted by copyman @copyman, Feb 13 5:43pm

RO said there was a trial going on that is a combo of HDR Brachy therapy and 5 sessions of Proton. Has anyone here heard of this or did it? Any insight would be greatly appreciated. Think I read about this combo TX somewhere on this or another forum but can't find anything about it now. Of course there is a lot of info on both as separate treatments. Thanks in advance

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for Jeff Marchi
Jeff Marchi | @jeffmarc | Feb 16 5:24pm
In reply to @wwsmith "@jeffmarc When @copyman mentioned 5 sessions of proton that has to mean proton radiation administered in..." + (show)
Profile picture for wwsmith @wwsmith

@jeffmarc When @copyman mentioned 5 sessions of proton that has to mean proton radiation administered in an SBRT format, right? That's the only way that you could get so few sessions. But if the trial is more concerned about comparing just proton to photon radiation, I suppose they could apply proton radiation in the same low dose way as photon IMRT radiation is applied in 25 sessions. That wouldn't be much of a trial as that would guaranteed work. But maybe the trial is intentionally wanting to test gentle proton radiation in a 5 session high dose SBRT format in order to see if that approach reduces the risk of toxicity when SBRT is applied in this way?

Jump to this post

@wwsmith
The normal way to do proton radiation is in 39 sessions like IMRT. Doing it in five sessions like SBRT and then adding HDR to it sounds to me like a really good trial. That is something they are doing now with SBRT for more advanced cases.

Definitely looking forward to what the results are, Unfortunately, it can take 10+ years to get the real feedback. The thing is, it shouldn’t take much to find out that it does work, I guess the question is do you get the same benefit of minimal damage to other tissue from just doing the one HDR session? Sure sounds like that’s what they are trying to find out, as you surmise.

REPLY
Profile picture for capatov
capatov | @capatov | Feb 16 8:16pm
In reply to @wwsmith "@capatov I too was wondering about the .1 PSA number you gave. You do get two..." + (show)
Profile picture for wwsmith @wwsmith

@capatov I too was wondering about the .1 PSA number you gave. You do get two decimal place accuracy on your PSA values, right? Which means your PSA was precisely 0.10. I had similar treatment as you. One year after a year of ADT, 26 IMRT treatments and one HDR brachy treatment my PSA is 0.13.

Jump to this post

@wwsmith the Emory Winship lab just gave me the .1 PSA reading and said it was excellent

REPLY
View MoreView Less
Please sign in or register to post a reply.