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Bone turnover markers (CTX and P1NP): do you have a baseline?
Currently i am on forteo therapy with a couple bone markers tests done. However, I didnt have ctx or p1np tested before the start of forteo as a baseline, regrettably.
It is known that the CTX value varies greatly among different individuals, with a very wide range. For post menopausal women, the range could be 34 - 1037 pg/ml; while for perimenopausal women 34-635 pg/ml. Different labs also have a slight different range values.
CTX, a bone resorption (breakdown) marker, is heavily influenced by a number of factors, such as food intake, circadian variation and exercise/life style, etc.
Bone remodeling is a dynamic and complex process. CTX itself may not fully reveal the whole picture. The bone building marker P1NP, is a lot less influenced by external factors. Taking both into consideration at the same time may shed more lights than looking at CTX or P1NP alone.
For those who had their CTX and P1NP tested before treatment with a bone drug, could you share the results if you don't mind? Thanks a lot!
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My last prescription from my GYN was written on his last day before retirement so I’m still in search of another GYN. My PCP can cover the med portion, if I ask him about it. The only difficult part being is he believes the Estradiol is not beneficial for me, so I’m not sure he would be on board with prescribing any. But in my 25 yrs of being on HRT none my GYN’s or my ND (BHRT) talked about doing a cream. Food for thought though, thank you
There are pros and cons for transdermal estradiol (gels, patches or vaginal creams) vs oral tablets, guess each practitioner has his/her own preference.
Please update us with your dxa results if you could when you complete evenity treatment, fingers crossed.
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2 ReactionsMy numbers were very similar to yours! I didn't have a baseline CTX, but my P1NP before Forteo was 32. After 12 months it was 135. Mt CTX after 12 months was 1355! But I didn't know about not exercising before the test. Between that and being on Forteo, my Dr. was not concerned. Hope she's right!
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1 Reaction@nwyatt, did you get a Dexa scan after 12mo on Forteo?
No, I have to wait one more year because of insurance coverage.
Thank you for sharing your experience. Would love to hear how things go for you as you continue - keep us posted!
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1 ReactionCan you say more about tymlos and Prolia taken together. I have not heard of this possibility but would like to know so that I can discuss with my endocrinologist.