Any risks taking bioidentical hormone injections for cancer patients?

Posted by pat9892 @pat9892, Aug 21 8:11am

What are the risks of having bio identical injections for cancer patients taking an estrogen blocker? Osteoporosis was diagnosed prior to IDBC. I had a bad reaction to bisphosphonate
and so stopped taking it.

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

Why not use a patch ?

REPLY

@pat9892, there are a few things to unpack in your message.

1. Bioidentical hormones: hormones marketed as "bioidentical" and "natural" aren't safer than hormones used in traditional hormone therapy. And there's no proof that they work any better. See this helpful information from Mayo Clinic experts:
- Bioidentical hormones: Are they safer? https://www.mayoclinic.org/diseases-conditions/menopause/expert-answers/bioidentical-hormones/faq-20058460

2. Find an osteoporosis medication that is right for you.
There are different types of osteoporosis medications, with different mechanisms of action. If bisphosphonates don't work for you, there are other options. This information might help you to talk about the options with your doctor.
- Osteoporosis treatment: Medications can help https://www.mayoclinic.org/diseases-conditions/osteoporosis/in-depth/osteoporosis-treatment/art-20046869

3. Osteoporosis and cancer medication
You mention that you had osteoporosis before diagnosed with breast cancer. You have estogen positive, invasive ductal carcinoma, right?
When taking cancer treatments that reduce estrogen, it can increase the risk of bone loss.

Were you on Zometa (zoledronic acid injection)? Have you discussed other medication options with your oncologist and endocrinologist?

REPLY

bioidentical estrogen hormones, including the estradiol patch are antithetical to SERMs in breast cancer patients.
They compete for the same receptors and wouldn't be a safe option for you.
Bisphosphonates are often prescribed for breast cancer survivors because of the risk of metastatic cancer to the bone. Prolia is an alternative, is also prescribed for osteoporosis. For some Prolia is an easy medication; for others a bundle of side effects.
Were you given an oral bisphosphonate or the IV Zometa. Some of the oral bisphosphonate are less strong than others.
Somatic testing of the tumor biopsy can give you a better idea of your risk for recurrence and metastasis, which could influence your medical decision.
I recommend National 1 but there are others, https://www.foundationmedicine.com/solution/foundationone-cdx If you haven't had the biopsy material tested, it's easy. They already have the biopsy material. You only have to request the testing from your oncologist.

REPLY
Profile picture for Colleen Young, Connect Director @colleenyoung

@pat9892, there are a few things to unpack in your message.

1. Bioidentical hormones: hormones marketed as "bioidentical" and "natural" aren't safer than hormones used in traditional hormone therapy. And there's no proof that they work any better. See this helpful information from Mayo Clinic experts:
- Bioidentical hormones: Are they safer? https://www.mayoclinic.org/diseases-conditions/menopause/expert-answers/bioidentical-hormones/faq-20058460

2. Find an osteoporosis medication that is right for you.
There are different types of osteoporosis medications, with different mechanisms of action. If bisphosphonates don't work for you, there are other options. This information might help you to talk about the options with your doctor.
- Osteoporosis treatment: Medications can help https://www.mayoclinic.org/diseases-conditions/osteoporosis/in-depth/osteoporosis-treatment/art-20046869

3. Osteoporosis and cancer medication
You mention that you had osteoporosis before diagnosed with breast cancer. You have estogen positive, invasive ductal carcinoma, right?
When taking cancer treatments that reduce estrogen, it can increase the risk of bone loss.

Were you on Zometa (zoledronic acid injection)? Have you discussed other medication options with your oncologist and endocrinologist?

Jump to this post

@colleenyoung Thank you for your helpful information and the links. Regarding bioidentical hormones and osteoporosis treatment. This was my first dive into the bio. hormones and it truly makes sense that they would be in conflict while taking an aromatase inhibitor. The only bisphosphonate I took was Risedronate. Reclast was suggested, but not knowing if I'd have an unwanted reaction I didn't want an injectable in my system for three months. My endocrinologist agreed with my decision to stop the Risedronate. She did say she had patients who'd taken AlgaeCal with good results. I do need to run that by the medical oncologist, at the suggestion of the dietician since in addition to a generally healthy diet, I also take some supplements. My upcoming oncology appointment will include labs (I've been keeping a diary of my food intake) so he can give me some good input before I see the endocrinologist a couple of weeks later. My 2 year DEXA isn't until mid November but I am exploring options prior to those appointments and I am willing to eliminate some of my present supplements as needed, if the AlgaeCal seems to be a good fit for bone strengthening. I do exercise which includes light weights in addition to walking 2-3 times per week.

REPLY
Profile picture for gently @gently

bioidentical estrogen hormones, including the estradiol patch are antithetical to SERMs in breast cancer patients.
They compete for the same receptors and wouldn't be a safe option for you.
Bisphosphonates are often prescribed for breast cancer survivors because of the risk of metastatic cancer to the bone. Prolia is an alternative, is also prescribed for osteoporosis. For some Prolia is an easy medication; for others a bundle of side effects.
Were you given an oral bisphosphonate or the IV Zometa. Some of the oral bisphosphonate are less strong than others.
Somatic testing of the tumor biopsy can give you a better idea of your risk for recurrence and metastasis, which could influence your medical decision.
I recommend National 1 but there are others, https://www.foundationmedicine.com/solution/foundationone-cdx If you haven't had the biopsy material tested, it's easy. They already have the biopsy material. You only have to request the testing from your oncologist.

Jump to this post

@gently Thank you for your response. I do not have metastatic BC. I was told that my biopsied sentintiel lymph node was metastatic, which is somewhat confusing to me. I self-detected IBC early , Stage 1A, grade 2 , and received an OncoDX genome score of 13, <4%, 9 yrs. so an optimistic diagnosis with lumpectomy, one lymph node biopsy, and 16 sessions of WB radiation, estrogen blocker for 5yrs. I had osteoporosis prior to my IBC but at that time I was not seeing an endocrinologist and was told to increase calcium & Vitamin D, which I did via supplements.
The Foundation One testing sounds quite comprehensive. I did have the My Risk Myriad Lab Assessment done. That came back with negative results it assesses multiple genes across 11 common cancers. In the past 15 months, I've tried to do as much research as possible, but there is so very much to read and thankfully so much ongoing research. There are also so many of us with so many different results which can be stressful, or discouraging, or hopeful. I marvel at so many of those I have connected with online or in person, their strength, perseverance and willingness to share their journeys so others may benefit. Best to you.

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Hi, Pat. It is inspiring to hear of women catching their own cancers in time to limit the damage.
It sounds like you had the testing for inherited cancers.
Somatic testing is done on the tumor alone. It tells you where the tumor would be likely to metastasize the bones, and which bones liver, brain or the lungs. It most commonly will migrate first to the lymph nodes. Pathologists refer to the node as metastatic, but that reference doesn't indicate metastatic breast cancer.
Information from this somatic testing of the tumor was so helpful to me that I think everyone with a cancerous tumor should have the testing done.
We all need to be aggressive with the research for the best outcomes.
Congratulations on your success.

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