1. < Prostate Cancer

‘Big Guns’ - Triple Therapy with Double Chemo - How to prepare?

Posted by dpfbanks @dpfbanks, Apr 15 7:53am

About to start treatment for what our medical team feels is a ‘sneaky’ metastasis due to low PSA + lung mets only situation. PSA 0.36 with 3 lung nodules about 1 cm each. We were hoping to start with something less, but trust the team. A little afraid, so looking for experiences with this combo or close to it: ADT (3 mos injections, likely Eligard), plus either Nubeqa or Abiraterone, plus Chemo of taxotere + carboplatinum X 6 sessions. This feels like a lot and probably is. He has had no treatment since prostatectomy 17 years ago, so it’s likely he is not yet castrate resistant… How to prepare? Hub has lost weight in the last 6 mos so hoping to beef up the diet with less animal/no sugar, but what can we expect?

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

dpfbanks | @dpfbanks | Apr 16 8:54am
In reply to @round5 "I had the exact treatment you are referring to with Nubeqa I completed over a year..." + (show)
@round5

I had the exact treatment you are referring to with Nubeqa I completed over a year ago. I immediately followed it with Pluvicto so I refer to my treatment with a prefix of Quad or Quinn(since there was Carboplatin and Pluvicto in addition to the triplet therapy so many refer to). I had my chemotherapy at Minnesota Oncology in Maplewood and my pluvicto at Mayo. I iced my head, my hands and my toes To prevent neuropathy And Hair loss. It was very effective. The Antiemetics Given worked great. I also wore the patch after to stimulate my white blood cell count, which worked great. I had about a week of mild nausea But had no trouble exercising and keeping my weight stable. But I was very healthy going into this. A long time runner and regularly lifted Moderate weights. I am one year out now, and my problem has been recovering my hemoglobin. I was at 10.3 A few months ago, and I’m scheduled next week for lab work. I have PET scans every three months and they have been pretty good stable at least, Some improved.

Jump to this post

SO helpful - We are looking into the iceing procedure - hair loss isan't a concern, but neuropathy is. Good to know about antiemetics. My hub is in pretty good shape - long time cyclist and athlete, but not much resistance work, which he will start. He has lost weight the last year and has a hip desperate for replacement, so that is put off now, and bummer because it really limits. He is big time into golf now - from windsurfing and telemark skiiing in his youth, so loss of stamina has a wide impact. Curious if the pluvicto was considered prior to chemo - but maybe not because that has just been approved. We still are investigating that, but it wasn't offered yet by our Mayo team. Its really helpful to hear your experience, so thank you again for replying.

REPLY
1 reply
northoftheborder | @northoftheborder | Apr 16 9:46am
In reply to @dpfbanks "Thanks - replies are SO helpful. I guess it is because its lung tissue and maybe..." + (show)
@dpfbanks

Thanks - replies are SO helpful. I guess it is because its lung tissue and maybe the team would consider later if there is residual tumor...? And good to hear no side effects - and 4 years out!

Jump to this post

I did get side effects from the radiation to the primary cancer in my prostate, which I had a few months later. They didn't emerge until a year after the therapy, and are annoying, but nothing that would have changed my decision if I'd known for sure in advance that I'd get them. That radiation was much stronger: 60 gy (vs 20). I had already talked with my oncology team and told them I wanted to treat the cancer aggressively, and they'd agreed to "throw the kitchen sink at it" — the radiation I got to my prostate was a so-called "curative" dose (even though my cancer isn't believed to be curable).

REPLY
round5 | @round5 | Apr 16 11:29am
In reply to @dpfbanks "SO helpful - We are looking into the iceing procedure - hair loss isan't a concern,..." + (show)
@dpfbanks

SO helpful - We are looking into the iceing procedure - hair loss isan't a concern, but neuropathy is. Good to know about antiemetics. My hub is in pretty good shape - long time cyclist and athlete, but not much resistance work, which he will start. He has lost weight the last year and has a hip desperate for replacement, so that is put off now, and bummer because it really limits. He is big time into golf now - from windsurfing and telemark skiiing in his youth, so loss of stamina has a wide impact. Curious if the pluvicto was considered prior to chemo - but maybe not because that has just been approved. We still are investigating that, but it wasn't offered yet by our Mayo team. Its really helpful to hear your experience, so thank you again for replying.

Jump to this post

You are correct. I had to have the chemotherapy before the Pluvicto. I too have a surgery that was postponed due to the cancer treatment. Right rotator cuff was scheduled and I then had to cancel it. Good luck 🙏

REPLY
View MoreView Less
Please sign in or register to post a reply.