Bempedoic acid to lower LDL (non statin)

Here is what Mayo Clinic recently reported:
https://www.mayoclinic.org/drugs-supplements/bempedoic-acid-oral-route/description/drg-20484223
It seems like it is usually used as an additional drug, but can be used by those who are statin-intolerant as well. I will be asking my cardiologist about it as I have "failed" 3 statins

Thank you. I would appreciate if you would want to share what the cardiologist thinks about this medication. I have been reading about it but whzt I don’t understand is that some physicians prescribe it with statins which doesn’t make sense when the patient doesn’t tolerate them. Anyway. I will keep an eye on responses. Have a great weekend. Stay healthy and safe. Thanks. Vivian

What I understand about when a cardiologist prescribes with a statin, is that the patient can only tolerate less milligrams of a statin than they actually need. When you put these two together it can lower cholesterol to an acceptable level.

Yes - I have been on it for 2 years. I have had no side effects and it is lowering LDL I am taking Nexletol, the one without Zetia. I had side effects with all statins...

The biggest problem is getting my insurance to cover it. It requires prior approval…and I am also on Repatha - both are expensive and no generics. Other than that…I haven’t had a single problem on it. If you get on it…stay away from Cipro and other fluoroquinolone antibiotics. Can cause tendon rupture.

Has anyone been prescribed bempedoic acid to lower cholesterol, LDL & Lipoprotein A? I started using Livalo (pitavastatin) but I have noticed it is affecting the motility in my bowel movements. I have never been constipated and just like that I needed to take Colace and Myralax. It id mentioned in the literature that constipation is one of the most noticeable side effects of statins.
I have been eating very healthy ( Mediterranean diet), no sweets, no sodas or alcohol. I drink 6 8-oz glasses of water everyday. I used to walk 1 mile or more everyday but I had a very bad episode of Covid for the first time which made me very weak and with no energy at all. I didn’t exercise for one month in December. Now that I feel better I am starting to walk like I did before. Let me know if anyone is taking bempedoic. Thank you in advance. Stay healthy and safe.

Yes, I have been on Nexletol for 3 years. I have not experienced one side effect, and it is working ok with Repatha to lower my cholesterol. My LDL is not where they want it, but much better than it was before these 2 meds.

A warning - the only big side effect is having to get a prior authorization from insurance. It is expensive. I hope you can try it with some free samples from your doctor…better to see if you have side effects before buying a supply. Esperion has a coupon program, but it is not as generous as others.

Here is to good health. Hugs to you.

All the best, Thea

Hi, I recently started a discussion about Nexletol and Nexlezet. Nexletol is the brand name for bempedoic acid. There have been a few interesting posts. The title of the post is “Any experience with Nexletol or Nexlezet?”

Has your prescription been expensive?

Bempedoic was just mentioned. I don’t think I will go there. It has worse side effects than the statins. The cost is around $439 but the physician should call your insurance to see if it covers it. Also you might ask if the pharmaceutical representative has some discount forms to fill out. I decided to keep on with my Mediterranean regime and everything I have been doing right to keep my lipids down.