Has anyone experienced back pain with Tymlos?

Posted by harryboy7 @harryboy7, Sep 25, 2025

I have started Tymlos recently. So far I am only doing 3 clicks. I know doctors and the Tymlos folks do not want us do that. Also the injections are to be given only in the stomach. There are other sites for subq injections. Tymlos and doctor say only inject into stomach.
Regarding the clicks, I plan to slowly titrate to full dose. My decision. I know a lot of people are doing this.
The main question I posted was back pain. Has anyone experienced that with Tymlos? Thanks

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

maymore | @maymore | Jan 22 12:19pm

The major spasming took about a week to subside, although it never fully stopped, which made me cautious every time I administered an injection. I experienced slight twinges afterward, and my stomach never felt quite right. I’ve never used a drug that elicited such an immediate and strong reaction, which was quite alarming. I asked my doctor about lowering the dose, but he said no. I realize I should have attempted it on my own to see if I could handle it as I was determined to make it work. Wishing you the best of luck with your experience! These drugs are not easy.

harryboy7 | @harryboy7 | Jan 22 4:44pm

Thanks for the reply. I did the Tymlos for 6 months and felt crappy. I had nausea for the 6 months. I took the full dose, although I did titrate in the beginning. My doctor also told me not to titrate. But I did it anyway. I think it was the safest way in order to see how your body reacts to the drug.
I went off the Tymlos as an experiment to see if anything changed. In about 2 days I felt normal, and didn't have anymore nausea. Now I am not sure what to do...I think it is important to take since my bones are in bad shape, but I not want to feel like crap for 2 years. So confused.

harryboy7 | @harryboy7 | Jan 22 4:48pm

Appreciate your feed back. I think I will try a lower dose also. I went off Tymlos for acouple weeks to see how I felt. For 6 months I took the full dose everyday, I had nausea and back pain.
After stopping, I felt normal. Now what do I do?