Anyone With PDAC and the HNF1A Mutation?
While 90% of PDACs have KRAS mutations, there is an HNF1A mutation related to late onset (or adult) Type 2 diabetes that may also be present in the tumor for a small number of patients. From what I've learned reading various papers, the HNF1A seems to be a factor in KRAS, but also has an effect on (or is affected by) some of the chemo protocols in wide use today (oxilaplatin, for one). HNF1A may also cause liver issues. So, I'm searching for others with this mutation combo. I'm curious about how your treatment protocols were adjusted and what your doctors have told you about this mutation and PDAC chemo protocols, if anything.