Anyone taking hrt even though they have an elevated risk of cancer

Posted by soggybones @soggybones, Dec 15, 2025

I have osteoporosis and I would love to go on hrt. My menopause symptoms are horrible and now with osteoporosis I want to go on hrt even more. The problem I have is that I have dense breast tissue and my mother had breast cancer so I'm already at an increased risk. Since I still have my uterus I would need progesterone as well and that makes my risk higher than if I was just on estrogen alone. Is anyone else familiar with what the new guidelines are for women like me?

Interested in more discussions like this? Go to the Osteoporosis & Bone Health Support Group.

Profile picture for gravity3 @gravity3

@nycmusic

Such a good reminder!
Does this improve my quality is now my mantra at 77.

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@gravity3 yes, my mantra, too….always emphasize it to docs !

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Profile picture for gargoy @gargoy

@loriesco, can you please tell me what dosage you take? And can I just tell my PCP it's "bioidentical HRT, or do I need a brand name? And what dosage of prometrium?
Thanks in advance!

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@gargoy depending on age and medical history, some PCPs prefer to defer HRT prescribing to an OBGYN, since decisions are usually based on cardiovascular and breast cancer risk assessment. Cardiologist(s) consultation may be needed also.

In mainstream medical practice setting, bio-identical HRT typically refers to FDA-approved transdermal estradiol (patches or gel) and oral micronized progesterone. Some docs still prescribe oral estradiol depending on preference and risk profile. Vaginal estrogen is often prescribed with little hesitation because systemic absorption is minimal.

In my case, my OBGYN prescribed transdermal estradiol 0.025mg/day (generic for Vivelle-Dot) along with nightly 100mg oral micronized progesterone (generic for Prometrium). Both are considered bioidentical. Im using them primarily for bone density maintenance, with monitoring of bone turnover markers to help guide dosing.

The progesterone dose is generally determined by the estradiol dose to ensure adequate uterine lining protection for those who have a uterus.

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