“Anyone take a Treatment Holiday? Intermittent use of ADT like Orgovy
I wish there was more info. on 'drug holidays' or 'intermittent use of ADT', with or without concurrent or prior surgery or radiation; especially as may relate to ADT 'orally alone' emphasizing Quality of Life, which may be a consideration particularly in order (over 75) men. I see plenty of discussion about side effects (common between ADT regimens it seems, whether injections or pills, which have lower long QT heart risk); but I see nothing dedicated to 'Orgovyx alone without any other treatment; and then 'if' one stops; and restarts… meaning is there an 'end point' of the course'; and then a patient does nothing more.
Maybe I saw one study in Japan; but not U.S. .. Again no discussion on say an older guy (over 75) taking Orgovyx … as ADT alone… without surgery or radiation. IE: QOL concern given it seems longevity is about the same (statistics don't help much; as once someone hits 80, longevity won't vary much regardless of treatment). So I'm wondering if 'ADT alone.. mono therapy' is a wise course. Also, is there info. on after successful year of treatment with Orgovyx and then PSA pops up a bit (say from .1 to 3. ..) will another few months restarted treatment be sufficient, and then 'do nothing' beyond. Or just skip it after going through a year of Orgovyx with the usual side effects (hot flashes etc.. )
May not be what supports clinics; but wonder if it's a quite reasonable choice (for 'localized' PC, Gleason Score 8; not metastasized). I have conflicting views from doctors; one for 'radiation' despite pacemaker; another: 'just pause the Orgo. and restart'; to lastly another doc: 'you had a course of Orgo; let things stabilize; enjoy life and don't think about it".
I realize there's no perfect answer; would appreciate reflections on this topic…especially if you did Orgovyx alone and stop and restarted or not. Thanks! I appreciate Coleen's efforts to help this group! (Lurking so far; my first post here ever.)