1. < Neuropathy

Anyone seen research on long term Proton Pump Inhibitor use and PN?

Posted by blearyeyes @blearyeyes, Aug 16, 2023

Anyone seen research on long term OTC Proton Pump Inhibitor use and PN?

I just read an article (on the internet) about anecdotal evidence of long term use of over the counter PPI use as a cause of Neuropathy along with a bunch of other issues.

I was told I would have to take PPIs for life for GERD by an Gastroenterologist 15+ years ago. Now they are saying don’t take more than 2 x 14 day runs a year.

Interested in more discussions like this? Go to the Neuropathy Support Group.

gently | @gently | Dec 6 8:55am
In reply to @bigjohnscho "I have taken a PPI (proton pump inhibitor) for many years due to acid reflux. I..." + (show)
@bigjohnscho

I have taken a PPI (proton pump inhibitor) for many years due to acid reflux. I now have peripheral neuropathy. I recently read that PPI’s over long term can cause neuropathy. Has anyone else experienced this

Jump to this post

https://pmc.ncbi.nlm.nih.gov/articles/PMC7716020/

REPLY
Mentor
John, Volunteer Mentor | @johnbishop | Dec 6 9:07am

@blearyeyes and others, Here's a research paper on the topic if you haven't already seen it.
-- How can proton pump inhibitors damage central and peripheral nervous systems?:
https://pmc.ncbi.nlm.nih.gov/articles/PMC7716020/

REPLY
Spreyton | @furdog | Dec 7 8:56am
In reply to @bigjohnscho "I have taken a PPI (proton pump inhibitor) for many years due to acid reflux. I..." + (show)
@bigjohnscho

I have taken a PPI (proton pump inhibitor) for many years due to acid reflux. I now have peripheral neuropathy. I recently read that PPI’s over long term can cause neuropathy. Has anyone else experienced this

Jump to this post

Do you have burning feet ?

REPLY
djhunt66 | @djhunt66 | Dec 8 1:00am
In reply to @bigjohnscho "I have taken a PPI (proton pump inhibitor) for many years due to acid reflux. I..." + (show)
@bigjohnscho

I have taken a PPI (proton pump inhibitor) for many years due to acid reflux. I now have peripheral neuropathy. I recently read that PPI’s over long term can cause neuropathy. Has anyone else experienced this

Jump to this post

PPI"s can makr you drficient on B12. Being deficient in B12 is one of the causes of neuropathy. I would have your b12 level checked.

REPLY
Moderator
Colleen Young, Connect Director | @colleenyoung | Dec 8 5:20pm
In reply to @bigjohnscho "I have taken a PPI (proton pump inhibitor) for many years due to acid reflux. I..." + (show)
@bigjohnscho

I have taken a PPI (proton pump inhibitor) for many years due to acid reflux. I now have peripheral neuropathy. I recently read that PPI’s over long term can cause neuropathy. Has anyone else experienced this

Jump to this post

Also see this related discussion:
- Anyone seen research on long term Proton Pump Inhibitor use and PN?: https://connect.mayoclinic.org/discussion/anyone-seen-research-on-long-term-proton-pump-inhibitor-use-and-pn/

REPLY
chrisanon | @chrisanon | Dec 9 5:14pm
In reply to @bigjohnscho "I have taken a PPI (proton pump inhibitor) for many years due to acid reflux. I..." + (show)
@bigjohnscho

I have taken a PPI (proton pump inhibitor) for many years due to acid reflux. I now have peripheral neuropathy. I recently read that PPI’s over long term can cause neuropathy. Has anyone else experienced this

Jump to this post

PPI's have been shown to cause Drug Induced Lupus. Try plain baking soda- look it up. I use about 1.8th tsp to 1/2 c water. Done with drugs (there are many!) that cause DIL.

REPLY
1 reply
jip499 | @jip499 | 6 days ago
In reply to @chrisanon "PPI's have been shown to cause Drug Induced Lupus. Try plain baking soda- look it up...." + (show)
@chrisanon

PPI's have been shown to cause Drug Induced Lupus. Try plain baking soda- look it up. I use about 1.8th tsp to 1/2 c water. Done with drugs (there are many!) that cause DIL.

Jump to this post

Baking soda is very high on sodium. Sodium can raise blood pressure.

REPLY
chrisanon | @chrisanon | 6 days ago

Thanks. Yes, I should have realized that. I got the tip from my G.P. lol sigh.

REPLY
View MoreView Less
Please sign in or register to post a reply.