1. < Colorectal Cancer

Anyone on Fruquintinib?

Posted by jmeath @jmeath, Mar 4 10:05am

My husband has metastatic colorectal cancer.
He was diagnosed over five years ago has since had multiple surgeries and has tried Folfox, Irox, and Lonsurf/Avastin with no luck.
Oncology mentioned trying the new treatment Fruquintinib. Wondering if anyone has tried it yet?

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paul28 | @paul28 | Mar 5 9:36am

Multiple surgeries over 5 years all related to metastasized colon cancer?
I imagine that this began with a colon resection or something more.
Could you share more details, please.

I have not heard of Fruquintinib.
Paul

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1 reply
jmeath | @jmeath | Mar 5 4:05pm
In reply to @paul28 "Multiple surgeries over 5 years all related to metastasized colon cancer? I imagine that this began..." + (show)
@paul28

Multiple surgeries over 5 years all related to metastasized colon cancer?
I imagine that this began with a colon resection or something more.
Could you share more details, please.

I have not heard of Fruquintinib.
Paul

Jump to this post

Yes, he started out stage 3 in 2018, had resection surgery & ended up with a colostomy bag. The cancer moved to his lung after a year, he had the spot removed. A mass was spotted on his spine/tailbone a year after that. They tried to remove it, but he almost bled out. He's also had both his prostate and bladder removed leaving him with a urostomy bag.
His first chemo treatment was Folfox/5FU, he almost died after the first dose. He did a radiation and oxaliplatin combo for a while. He switched to IROX plus more radiation with no luck. He recently ended the Lonsurf and Avastin combo. He just hasn't seen any significant results.
I guess the drug Fruqunitinib was recently FDA approved in November of 2023, it's specifically for colorectal cancers, a new doctor on his team suggested it.
I guess we were hoping to get more information from someone who has already started it.

REPLY
2 replies
paul28 | @paul28 | Mar 5 5:44pm
In reply to @jmeath "Yes, he started out stage 3 in 2018, had resection surgery & ended up with a..." + (show)
@jmeath

Yes, he started out stage 3 in 2018, had resection surgery & ended up with a colostomy bag. The cancer moved to his lung after a year, he had the spot removed. A mass was spotted on his spine/tailbone a year after that. They tried to remove it, but he almost bled out. He's also had both his prostate and bladder removed leaving him with a urostomy bag.
His first chemo treatment was Folfox/5FU, he almost died after the first dose. He did a radiation and oxaliplatin combo for a while. He switched to IROX plus more radiation with no luck. He recently ended the Lonsurf and Avastin combo. He just hasn't seen any significant results.
I guess the drug Fruqunitinib was recently FDA approved in November of 2023, it's specifically for colorectal cancers, a new doctor on his team suggested it.
I guess we were hoping to get more information from someone who has already started it.

Jump to this post

Thank you for offering those details of a horribly sad five years that your husband has endured and survived. It is truly an amazing story of the human cruelty that cancer imposes.
May he receive the blessing of a medical miracle in recovery!

REPLY
cjay | @cjay | Mar 5 11:01pm
In reply to @jmeath "Yes, he started out stage 3 in 2018, had resection surgery & ended up with a..." + (show)
@jmeath

Yes, he started out stage 3 in 2018, had resection surgery & ended up with a colostomy bag. The cancer moved to his lung after a year, he had the spot removed. A mass was spotted on his spine/tailbone a year after that. They tried to remove it, but he almost bled out. He's also had both his prostate and bladder removed leaving him with a urostomy bag.
His first chemo treatment was Folfox/5FU, he almost died after the first dose. He did a radiation and oxaliplatin combo for a while. He switched to IROX plus more radiation with no luck. He recently ended the Lonsurf and Avastin combo. He just hasn't seen any significant results.
I guess the drug Fruqunitinib was recently FDA approved in November of 2023, it's specifically for colorectal cancers, a new doctor on his team suggested it.
I guess we were hoping to get more information from someone who has already started it.

Jump to this post

@jmeath
It’s hard to imagine feeling hopeful on such a painful difficult road, so kudos for you both for looking forward!
My brother-in-law has been sending me links to that drug plus a promising vaccine in trial stages.
The first 2 links are for that specific drug, the 3rd is to another that might be helpful. It sounds like your team is very aware of all the new trials and studies for mcrc, and I hope they find something that really helps!😘💗🌹

https://www.takedaoncology.com/news/news-releases/Takeda-Receives-US-FDA-Approval-of-FRUZAQLA-fruquintinib-for-Previously-Treated-Metastatic-Colorectal-Cancer/

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https://www.cancernetwork.com/view/fruquintinib-combo-improves-quality-adjusted-survival-in-metastatic-crc

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https://www.fiercepharma.com/pharma/asco-merck-s-keytruda-doubles-time-to-disease-progression-certain-colorectal-cancer-patients

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magsbrad | @magsbrad | Mar 7 6:22pm

It’s just been passed in UK for use but our NHS are very slow. It can be purchased at $8000 a month and be prescribed and monitored by a qualified doctor. I’m not sure how it works in US with insurance. In UK it is paid for but they probably won’t offer it in time for many. So if you have the cash and a doctor to prescribe and monitor you can have it now. It’s in tablet form and as you can see very expensive. It’s for stage 4 colon cancer. I am going to try and get it if my recent results are bad. Hope this helps.

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