Anyone on Calquence as first line treatment for MCL?

Posted by jda28 @jda28, 2 days ago

My 33 year old daughter was diagnosed 5/13/25 with MCL as confirmed through tonsillectomy pathology report.
Stage 3 shifted to stage 4 after bone marrow biopsy shows limited involvement. Treatment plan is Calquence BTK Inhibitor followed by CAR-T Cell Therapy.

I’m glad to have found this support group. Wishing everyone well.

Interested in more discussions like this? Go to the Blood Cancers & Disorders Support Group.

Lori, Volunteer Mentor | @loribmt | 1 day ago

Welcome to Connect, @jda28 though I wish it were under less stressful circumstances. Your daughter is on quite a medical journey with Mantle Cell Lymphoma at such a young age. Being a mom myself, I know how that occupies your thoughts.

There is a discussion in the forum with other members who also have been diagnosised with MCL. I posted the link for you. It is a dated discussion but you can reverse the order to read the more current replies.
https://connect.mayoclinic.org/discussion/mantle-cell-lymphoma/
From my understanding, Calquence (Acalabrutinib) is one of the targeted first line treatments for MCL and other forms of Lymphoma such as CLL. This may help bring her into remission so that she can receive CAR-T cell therapy.

CAR-T has been gaining so much ground over the past years with the advancement in treating diseases such as MCL.
Of course there’s another support group for CAR-T. ☺️ You may want to peruse through the conversations with members such as @4health4bonnie kirkwilliams2049 @anthea29 and others who recently had the CAR-T for their blood conditions. The link is below:
~CAR-T Cell Therapy: Introduce yourself and connect with others https://connect.mayoclinic.org/discussion/car-t-cell-therapy-introduce-yourself-and-connect-with-others/

Has your daughter had a good response to the Calquence?

jda28 | @jda28 | 1 day ago

In reply to @loribmt "Welcome to Connect, @jda28 though I wish it were under less stressful circumstances. Your daughter is..." + (show)

Lori - thank you for your kindness and helpful links.

Her bloodwork looked good at her recent 2-week check in. Next bloodwork is 9/15.
Tolerable side effects for now. Phew.

🙂

Lori, Volunteer Mentor | @loribmt | 1 day ago

In reply to @jda28 "Lori - thank you for your kindness and helpful links. Her bloodwork looked good at her..." + (show)

That’s awesome news! Sounds like the Calquence is doing its job! Wishing your daughter (and you) all the best! Please keep me updated, ok?

jda28 | @jda28 | 1 day ago

In reply to @loribmt "That’s awesome news! Sounds like the Calquence is doing its job! Wishing your daughter (and you)..." + (show)

For sure I’ll post updates.

We’re celebrating any good news. 🌻

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