Connect
Anyone on a TKI develop atherosclerosis?
hi all - just wondering if anyone else has developed atherosclerosis after being on a tyrosine kinase inhibitor, especially longer term use. it might be coincidental timing but my lipid panel has always been normal and I don't have other risk factors. 🤔
Like
Helpful
HugInterested in more discussions like this? Go to the Lung Cancer Support Group.
Connect
@mamajite, has it been confirmed that you have atherosclerosis (buildup of fats, cholesterol and other substances in and on the artery walls)? How is it being managed?
hi @colleenyoung - yes, it was an incidental finding on an abdominal CT checking for metastasis. my PCP wants to put me on a statin (for life), but I'm curious if there's any chance it might resolve, or behave differently now that I'm off osimertinib. I'd also like to know if there's a causal link, as it could impact whether or not I could take the medication in the future.
there's not a lot of information available, but I did find this paper:
"Tyrosine kinase inhibitors and atherosclerosis: A close but complicated relationship"
https://www.sciencedirect.com/science/article/abs/pii/S0014299923003801