anyone had a muscle biopsy and result of type 2 muscle fiber atrophy?

Posted by bprather @bprather, Jan 12 8:42am

hey everyone!
i am a 26 year old female i was healthy december 2024 and January 2025 it all came tumbling down and hit me like a rock!!! i have been searching for answers for a year now with little diagnosis along the way but no one can figure out what the main source is i got diagnosed with spinal stenosis, herniated disc, spondylolisthesis, raynaud’s phenomenon, lyme disease, and prurigo nodularis. none of these really correlate with eachother and my symptoms aren’t textbook. i have done a myositis blood panel 3 times and everytime my MI-2 is positive and keeps going up. my CK is always normal ive had 2 EMGs that were abnormal and both were widespread increased insertional activity dennervation without reinnervation and CRD + myotonic discharges. i recently had a muscle biopsy. and all it showed was type 2 muscle atrophy and does not match with myositis. so i am very confused and wondering if anyone else has gotten a muscle biopsy with the same result and what you got diagnosed with ? what your next steps were? or any advice or help would be greatly appreciated!!

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Thank you for posting. I have several conflicting signs and now going to see a specialist in polymyositis (that actually treats this rare disorder) to see what possible subset. Very confusing and a two year journey.

My suggestion to you, is to maybe google lumbar instability because if the general muscles have weakened surrounding the spine, then your core muscles will be weak. One spinal doctor told me at the beginning of my journey to exercise core muscles to strengthen, never asking why these might be weakened.

I have not had a muscle biopsy yet but your information will help me know what to ask.

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Profile picture for bresue @bresue

Thank you for posting. I have several conflicting signs and now going to see a specialist in polymyositis (that actually treats this rare disorder) to see what possible subset. Very confusing and a two year journey.

My suggestion to you, is to maybe google lumbar instability because if the general muscles have weakened surrounding the spine, then your core muscles will be weak. One spinal doctor told me at the beginning of my journey to exercise core muscles to strengthen, never asking why these might be weakened.

I have not had a muscle biopsy yet but your information will help me know what to ask.

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@bresue
Thanks for the suggestion.ill be speaking to my rheumatologist this week. Can y take it any more! So tired I couldn’t even vacuum my kitchen!

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