Any suggestions on what time of day is best for taking Hydroxyurea?

I have been taking Hydroxyurea 500 MG twice a day for about 5 years. I was taking in the AM and in the PM. Since my platelets are low and stabilized, I now take once a day. I have taken it in the morning and in the evening. It does not seem to matter when I take it. The drowsy monster comes upon me about 4pm every day. I can struggle through with minimal mental tasks after that until about 7 pm when I am not able to do much other than watch television. Luckily watching television requires no mental activity. Then I go to sleep about 8 pm. I have arranged to do everything demanding in my life prior to 4pm. Other than that I have no other side effects. The days of my wild late nightlife youth are over for me. I don't really miss them. I wish you all the best, from the heartland of America, Kentucky.

I take hydroxyurea, 500 MG each night at 9 pm. I have been on it for 2 months. I am a little sleepy throughout the day. I take small naps as needed. I still have enough energy to do what needs to be done.

I take 500 mg on MWF. I take them at bedtime.

I found that taking hydroxyurea around 9 p.m. worked best for me. I tried taking it in the morning but the drowsiness and becoming a bit clumsy due to hydroyurea had me change to a 9 p.m. dose.

At the start my hematologist recommended a half hour before or after a meal, I have tried different ways. I prefer after lunch. You need to drink a minimum of 64 ounces of water a day to get rid of the toxic effect.
Best wishes, Eileen

I take 500mg daily.
I was very tired taking HU in the a.m. so I tried after dinner.
No change - just as tired..🥱
My worst symptom is short of breath.

I'm only taking 1 500mg daily & was just curious if any one had noticed if a specific time of day works better over others when it came to any possible side effects.

I take two 500 mg capsules 4 days a week - one with breakfast and one with dinner. I like taking medications with food whenever possible as I believe it mitigates possible stomach-related side effects. Regardless, it works for me and my hematologist-oncologist is fine with it.