Any suggestions on what time of day is best for taking Hydroxyurea?

I've been taking my daily 600 mgs(Droxia) in the evening, along with my other meds, for the past 6yrs. It has worked for me--lowered my platelets to normal range, while keeping other counts normal, and preventing splenomegaly.

Strange. I take Hydro 500 mg twice a day and have never felt anything different. I was never told to drink lots of water or take at any time that that would be best. I just take it with my morning supplement pills and before bed again with my supplements. But, two years ago my PLT count was 2057 and I was very fatigued, so I started with Hydroxyurea and in Aug 2024 my PLT was down to 671. Not where it's suppose to be but a great improvement!

My hematologist recommended a half hour before or after eating. I was also told to drink a full glass of water with it. It is also recommended to have 64 ounces of fluids daily to guard against the toxicity of Hydroxyurea.

Taking right before bedtime gave me bad dreams, so taking sometime after dinner works best for me. (Taking in the morning made me drowsy.)

I found it works best for me to take it in the evening as well. I figured if it’s going to make me lightheaded and tired it might as well be before I go to bed.😊

I take mine before I go to bed. Works for me

I take my HU at 7PM(after dinner) every night.. That has worked out well for me…

Very interesting, I get short of breath alot

I've been on HU for 3 years now. Dr said to take both caps at same time. I take a 730pm about 1 1/2 hr after dinner and 1 1/2 hour before bedtime, as I drink at least 10 ounces of water with caps. Sometimes I also take a few spoonfuls of yogurt or cottage cheese. I think everyone is different, you just have to find your sweet spot. I have my devices set off alarm so I don't forget.

I don't sleep well and avoid taking in the evening, just in case I have any stomach issues. I take each morning with my breakfast, drink lots of water ( to help flush the toxins ) and avoid long term exposure to the sun. I take the same dosage as you do and do not have any side effects from this medication. Most of the side effects mentioned in these posts can be attributed to the aging process...dry itchy skin, bruising, fatigue, hair loss, etc. The aspirin we all probably take with our hydrea is more likely to cause stomach upset. I take coated aspirin with my meals as well. I have experienced no side effects at all in the last three years. I am 66 years old.