Any suggestions on what time of day is best for taking Hydroxyurea?

May I ask why you're taking this medication for? What is your diagnosis?

Has anybody had any eye issues with?myelofibrosi?

I just started taking this 4 days ago, I take it in the evening at 6:30, after I've had something to eat. So far so good

Thanks so much for the encouraging news.

Chances of Hydrea side effects are low for most of us due to the low dosage needed to regulate our blood. However, some of us do have negative reactions. Hair loss is NOT a side effect of the medication in the dosage we need, but can be caused by stress and/or is age related (since most of us are upwards of 60). The mouth sores, which are a reported side effect, can be alleviated with proper hydration.

Very helpful! Thanks for chiming in.

70 yo, ET-CALR x 15 years. Have been on HU x 6 years (500 mg per day plus extra on M-W-F). Doc calls this a low dose.

Had the proverbial "cast iron stomach" as a young person and could eat anything. Alas, those days are over, and I have some acid reflux, low level nausea, and trouble w gas and constipation. Oncologist suggested probiotic, and it has helped quite a bit. My spleen wasn't enlarged last check, but I do have some early satiety, so I eat smaller meals thru out the day.

Good morning all,
What works for me is to tilt the Hydroxyurea out of the bottle into a second small lid (some buy small paper cups). I have water swirled already in my mouth, tilt the capsule in, and swallow. I follow up with a full glass of water…i never get mouth sores.
Eileen

I joined the PV club in 2018. I have been taking the "Hydra" for almost 6 years now. I started at 500 mg 2 times a day. My platelets are under control now (in the 277 range). I now take 500 mg once a day. I have taken it in the morning, I have taken it at later at night. I see no difference in the times. No matter when I take it, I get the ususal fatigue in the late afternoon and must go to sleep by 9pm. This makes it difficult to stay up late watching scary Halloween movies. I don't have many symptoms other than that. Hope my humble opinion will help. From Kentucky, where the bluegrass feels good under your barefeet.

Thank you for this. I've just been on Hydrea for two weeks. How long before the symptoms start - ulcerations in the mouth, hair loss, and pain in various parts of the body (if any).

So far, it's just tingling on the tongue, and I take Acidophilus for that so that it doesn't get out of hand. Any info you have would be much appreciated.
Thank you.