Any suggestions on what time of day is best for taking Hydroxyurea?

I take two 500 mg capsules 4 days a week - one with breakfast and one with dinner. I like taking medications with food whenever possible as I believe it mitigates possible stomach-related side effects. Regardless, it works for me and my hematologist-oncologist is fine with it.

I'm only taking 1 500mg daily & was just curious if any one had noticed if a specific time of day works better over others when it came to any possible side effects.

I take 500mg daily.
I was very tired taking HU in the a.m. so I tried after dinner.
No change - just as tired..🥱
My worst symptom is short of breath.

At the start my hematologist recommended a half hour before or after a meal, I have tried different ways. I prefer after lunch. You need to drink a minimum of 64 ounces of water a day to get rid of the toxic effect.
Best wishes, Eileen

I found that taking hydroxyurea around 9 p.m. worked best for me. I tried taking it in the morning but the drowsiness and becoming a bit clumsy due to hydroyurea had me change to a 9 p.m. dose.

I take 500 mg on MWF. I take them at bedtime.

I take hydroxyurea, 500 MG each night at 9 pm. I have been on it for 2 months. I am a little sleepy throughout the day. I take small naps as needed. I still have enough energy to do what needs to be done.

I have been taking Hydroxyurea 500 MG twice a day for about 5 years. I was taking in the AM and in the PM. Since my platelets are low and stabilized, I now take once a day. I have taken it in the morning and in the evening. It does not seem to matter when I take it. The drowsy monster comes upon me about 4pm every day. I can struggle through with minimal mental tasks after that until about 7 pm when I am not able to do much other than watch television. Luckily watching television requires no mental activity. Then I go to sleep about 8 pm. I have arranged to do everything demanding in my life prior to 4pm. Other than that I have no other side effects. The days of my wild late nightlife youth are over for me. I don't really miss them. I wish you all the best, from the heartland of America, Kentucky.

I don't sleep well and avoid taking in the evening, just in case I have any stomach issues. I take each morning with my breakfast, drink lots of water ( to help flush the toxins ) and avoid long term exposure to the sun. I take the same dosage as you do and do not have any side effects from this medication. Most of the side effects mentioned in these posts can be attributed to the aging process...dry itchy skin, bruising, fatigue, hair loss, etc. The aspirin we all probably take with our hydrea is more likely to cause stomach upset. I take coated aspirin with my meals as well. I have experienced no side effects at all in the last three years. I am 66 years old.

I've been on HU for 3 years now. Dr said to take both caps at same time. I take a 730pm about 1 1/2 hr after dinner and 1 1/2 hour before bedtime, as I drink at least 10 ounces of water with caps. Sometimes I also take a few spoonfuls of yogurt or cottage cheese. I think everyone is different, you just have to find your sweet spot. I have my devices set off alarm so I don't forget.