Any connection between Neuropathy and MCAS?

Posted by pennycurious1 @pennycurious1, Dec 18, 2025

I am one of the seemingly millions of people round the globe suffering from neuropathy.

My symptom pattern is immensely diverse with the main symptom of course being pain. However, I have been diagnosed with other sideline symptoms such as a huge histamine overload (not allergic) due to a systemic disorder called Mast Cell Activation Syndrome. I wonder whether there could be any connection between this syndrome and my neuropathy pains.

Any experience or knowledge about this?

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nurse1963 | @nurse1963 | Jan 13 9:32am

I was on it for about 4-5 months. Didn’t realize that it was stronger than xolair until I went back on it. The first week after the injection I was hyper-like hyperthyroidism. Then the second week of the month I was depressed all week. The third week symptoms got better and by the forth week my moods were back to normal. This happened month after month. Like I said it is stronger than xolair. My doc says that it stops the allergic pathway before it starts. Didn’t want to feel like I was bipolar (I’m not) for the rest of my life. Still trying everything under the sun. I think that my body needs a break for awhile. Just got off of gabapentin cold turkey because my blood sugar was 245.