antibody testing laboratory

Posted by 2catmom @2catmom, May 7, 2023

I’m looking for a US facility that will test for IgM antibodies to the phosphatidylserine-prothrombin complex (IgM aPS/PT.) Clinicians from Japan report this antibody correlates with cutaneous polyarteritis nodosa.
While it’s still off-label, testing for the IgG antibody to the same phosphatidylserine-prothrombin complex (IgM aPS/PT) is sometimes done when profiling antiphospholipid syndrome patients.

If you’ve been tested for antibodies to the phosphatidylserine-prothrombin complex, might you share the name of your testing lab?

Interested in more discussions like this? Go to the Autoimmune Diseases Support Group.

John, Volunteer Mentor | @johnbishop | May 8, 2023

@2catmom, While we wait for others who may be able to share names of their specific testing labs in the U.S., I found a few that may be what you are looking for:

--- Mayo Clinic Laboratories - https://www.mayocliniclabs.com/test-catalog/Overview/64704
--- Labcorp - https://www.labcorp.com/tests/504439/antiphosphatidylserine-prothrombin-complex-igg

kstar077 | @kstar077 | May 8, 2023

Quest diagnostic

kstar077 | @kstar077 | May 8, 2023

Quest diagnostic
Labcorp

2catmom | @2catmom | May 8, 2023

The support on Mayo Clinic Connect is wonderful!

Thanks @johnbishop for the Mayo Clinic and LabQuest links. From the CPT codes on those sites, I followed up on @kstar077 Quest suggestion and found Quest’s version https://testdirectory.questdiagnostics.com/test/test-detail/11447/phosphatidylserineprothrombin-pspt-antibodies-igg-igm?cc=MASTER

Amy

P.S. for those interested in the arguments for testing, here are some urls

open source
cPAN 2010 https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1346-8138.2009.00761.x
cPAN 2020 https://www.clinexprheumatol.org/article.asp?a=14687
APS 2014: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408156/pdf/cei0180-0218.pdf

paywall
APS 2019 https://www.sciencedirect.com/science/article/abs/pii/S0272271219300575

2catmom | @2catmom | Jun 20 11:08am

Have you and your care team found that periodic Vectra® panels (12 serum proteins) is useful for tracking your autoimmune condition(s)?

It’s a trademarked test from Labcorp used to guess-timate risk of x-ray detectable joint changes from arthritis. Labcorp suggests annual screening for folks with rheumatoid arthritis

Like many of you, I have more than one autoimmune diagnosis. Mine manifest in the skin: psoriatic arthritis on top of a rare vasculitis (cutaneous polyarteritis nodosa.)

I just got the results from my initial Vectra® panel. I’m wondering if annual Vectra screening has proved informative for any members of this autoimmune conditions group.

Thanks!
https://www.labcorp.com/treatment-areas/rheumatology/clinical-testing/vectra
https://www.labcorp.com/tests/504965/vectra

pm56 | @pm56 | Jun 21 10:31am

In reply to @2catmom "Have you and your care team found that periodic Vectra® panels (12 serum proteins) is useful..." + (show)

I had one done back in 2019 for the first time and I noticed the new rheumatologist I've been seeing ordered it as well (the old one probably ran it more often than that the one time, but I probably wasn't paying close attention). I increased from a 21 to a 42 - when I asked the new rheumatologist if that meant my risk had increased based on the labs, she sort of shrugged and said, "Well, I run it, but to be honest I don't think the results always correlate to reality" . . . My understanding is where it's most helpful is in guiding doctors with patients who are seronegative for RA, but are symptomatic. The panels can help them figure out what's going on if their TNF-alpha or interleukin-6 levels are elevated despite negative rheumatoid factor and Anti-CCP labs which are commonly associated with RA. In my case I have high RF with negative Anti-CCP, but I have mostly back and hip inflammation - but I don't have the HLA-B27 protein that is usually linked spondyloathropathy. I'm a mixed bag of labs that don't match symptoms and vice versa, which is why I think both doctors have run the Vectra to see if it can give them any additional useful information into what my immune system is doing. Hope that sort of helps!