What antiviral medication is right for people with blood cancer?

What antiviral for Covid-19 is suitable for a patient with B cell lymphoma, Afib, and on Xarelto?
Paxlovid may not be indicated for those on blood thinnes?? What would be recommended?
What is the meaning and significance of MYD88 finding?

Hi @jam5. I wish we could help answer your question but the only source for “What is the best of antiviral for Covid in a patient with pre-existing conditions of any Lymphoma and Afib” is your hematologist/oncologist and cardiologist, or Pharmacist. This is by prescription only and no one on our forum can answer this for you. Is your husband newly diagnosed with Covid or are you lining this up just in case?? If you find out, will you let us know, please?

However, I can help answer your question about the MYD88 Gene.

Medline Plus-Genetics provided this publication on their site which explains the MYD88 gene and its normal roll in the immune system. I’ve pasted the first paragraph here for you.

“The MYD88 gene provides instructions for making a protein involved in signaling within immune cells. The MyD88 protein acts as an adapter, connecting proteins that receive signals from outside the cell to the proteins that relay signals inside the cell. In particular, MyD88 transfers signals from certain proteins called Toll-like receptors and interleukin-1 (IL-1) receptors, which are important for an early immune response to foreign invaders such as bacteria. In response to signals from these receptors, the MyD88 adapter protein stimulates signaling molecules that turn on a group of interacting proteins known as nuclear factor-kappa-B. Nuclear factor-kappa-B regulates the activity of multiple genes, including genes that control the body's immune responses and inflammatory reactions. It also protects cells from certain signals that would otherwise cause them to self-destruct (undergo apoptosis).”
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Here’s the actual site about MYD88 with various sub-articles that might be helpful for you if you have other questions about that gene and any mutations/conditions. It’s a really good informational article. https://medlineplus.gov/genetics/gene/myd88/#conditions

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I think last year when we first starting chatting there was some question of your husband having WM? But I think that diagnosis is no longer in question as he has B-Cell Lymphoma. One of your questions at that time, was whether mutations for the MYD88 gene is always checked with a bone marrow biopsy/exam.
We all have that gene. But a specific, aquired mutation to the gene can signal WM. It is a way to help determine WM if it’s suspected.

What were the results of the test? Did it show a mutation to the MYD88 gene or is it just present?

Thank you for your response.
I am just asking to know should he become infected what would be available as I seem to recall hearing blood thinners contraindicate Paxlovid, and the concern for rebound infection.
The oncologist seems to feel he has Marginal Zone B Cell Lymphoma at this time; however, I still have questions.
I will follow-up with the MYD88.
Thank you again

It’s really a great idea to have a plan. Don’t hesitate to give a call to his doctors so it’s lined up ahead of time ‘just in case’. I’m sure they have patients asking all the time because of reaction with some blood thinners. Hopefully it won’t ever be needed or an issue, but it’s better to be on the safe side. ☺️

It’s good to keep asking questions and I’m interested in the MY88 findings too, so let me know what you find out if you don’t mind. Like I mentioned it is a normal gene. But if it develops a mutation which causes it to stray from its normal function, that’s where the body runs into trouble.

It’s really a great idea to have a plan. Don’t hesitate to give a call to his doctors so it’s lined up ahead of time ‘just in case’. I’m sure they have patients asking all the time because of reaction with some blood thinners. Hopefully it won’t ever be needed or an issue, but it’s better to be on the safe side. ☺️

It’s good to keep asking questions and I’m interested in the MY88 findings too, so let me know what you find out if you don’t mind. Like I mentioned it is a normal gene. But if it develops a mutation which causes it to stray from its normal function, that’s where the body runs into trouble.

You are right, there are a lot of warnings regarding antivirals interacting with other medications. This is definitely a question for your doctors, especially your cardiologist.
Do you have Covid now, or are you just trying to figure this out in case you test positive?
Sue