Another round of different drugs

Posted by oldfords @oldfords, Jan 30 2:21pm

Well two years ago I was told I had prostate cancer with a PSA of 363. I did 6 rounds of chemo and have been on Lupron and Nubeqa the entire time. My new pet scan shows most of the tumors are stable but two are growing rather quickly. My Dr. now says I should go from the Lupron shots to a Lupron pill each day, and stay on the Nubeqa. The biggest change will be the addition of 6 rounds of Pluvicto. Anyone had experience with this?

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

jeff Marchi | @jeffmarc | Jan 30 5:35pm

It is not a Lupron pill. The pill form of ADT is called Orgovyx. It actually works a little differently since it is antagonist and Lupron is an agonist.

I know a lot of people who have had Pluvicto. I’ve also been to a couple of different 1 hour seminars where they’ve spent the whole time talking about Pluvicto.

Be aware that it works really well for 33% of people OK for 33% of people and not at all for 33% of people.
If you have certain genetic issues, either hereditary or somatic, it can affect how well Pluvicto Works. You can ask for a somatic test before doing Pluvicto To find out if you’ve got Genetic changes Due to the cancer.

If you have BRCA2 or ATM It seems to work better. If you have RB1, PTEN or TP53 They are Pluvicto resistant.

Peter Kafka Who moderates the reluctant brotherhood advanced prostate cancer meeting Has had prostate cancer for 12 years. His PSA started rising, so he had two sessions of Pluvicto And his PSA went down to .05. He’s holding the other four sessions off until his PSA starts rising again. You could join his meeting And talk about it.

Another person’s feedback
My husband had six Pluvicto infusions over most of 2024 and had none of the severe side effects that some people experience. He had some fatigue, a dry mouth from his saliva glands being affected by the treatment, and his appetite for food decreased in that most things just didn't appeal to him. His last Pluvicto infusion was in August 2024, and the only side effect remaining is dry mouth. Please don't worry about the radioactivity warnings; your doctor or treatment staff should tell you what is necessary, and it is much less than the overkill that some men do. No need to buy a Geiger counter or totally isolate yourself for days!

Some people have more side effects than this person mentioned others people have fewer. It’s a lot easier than chemo.

brianjarvis | @brianjarvis | Jan 31 5:36am

On 4/16/2024, you posted that your prostate cancer “showed widespread osteoblastic.”
> is the prostate cancer still only spread to bone?

If so, there might be a different isotope therapy (other than Pluvicto) for you to discuss with your medical team.

oldfords | @oldfords | Jan 31 8:17am

Yes, I think so. It is not in any organs at this time.

jeff Marchi | @jeffmarc | Jan 31 10:57am

In reply to @oldfords "Yes, I think so. It is not in any organs at this time." + (show)

@oldfords
For prostate cancer that has spread to only the bone radium 223 (xofigo) Is one of the recommended treatments? Ask your doctor about it. If you’re only seeing a Urologist, they may not be the right doctor to talk to you about this.

oldfords | @oldfords | Feb 1 8:01am

Thanks Jeff, You have given me some great questions to ask my cancer Dr. I am going to txt her tomorrow and try to get some answers. Again thanks to all