Anastrozole Brain Fog

Posted by lisman1408 @lisman1408, Jan 17, 2019

I started taking Anastrozole in October 2018 after radiation for stage 2 breast cancer. Has anyone had ‘brain fog’ or memory loss with this medication? If so, what have you done to relieve this annoying side effect?

Interested in more discussions like this? Go to the Breast Cancer Support Group.

Profile picture for eku @eku

A question I have is, I personally know many women in academia, research, teaching, management positions who are well beyond their menopausal age and doing a wonderful job. So, if cognitive decline is due to the lack of estrogen, how are we going to explain these brilliant women? If it is due to the estrogen blocking medication, then can we say that there's a difference between the cognitive decline due to menopause vs cognitive decline due to the estrogen blockers?

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Some women go through menopause with nary a symptom. Some women experience it as a nightmare. So perhaps this is due in part to varying levels of estrogen lost and/or retained. If a women starts out brilliant, she could go through mild menopause and still remain brilliant. I personally was on Anastrozole and then Letrozole. When I took a 30 day break from Letrozole i noticed the difference. And I dare say I still have my aha! moments but will struggle to come up with a particular word. Brilliant women can retain their brilliance, but they may just have to work a little harder at it. AI's don't make us stupid, but they do make us work harder.

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Profile picture for mglinkhart @mglinkhart

This is my second go round with breast cancer. I took exemestaine the first time now I’m on Anastrozole and I’m losing my words again. Soo I told my family snd friends if I can’t remember a word I will say bucket instead and that way I don’t have to struggle trying to find the right word and they understand I can’t remember. It’s easier on all of us and I don’t get my feeling hurt.

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Great idea saves from the frustrations you get from not remembering

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I found an NIH study titled “The Impact of Obesity on Breast Cancer Diagnosis and Treatment” published on 2019 Mar 27. This is not the original study that I saw that implicated weight as a factor in BC treatment but this one is pretty good.

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Profile picture for gldilli @gldilli

I am curious if weight influences Anastrozole side effects. The standard dose of 1 mg might work differently for a 150 lb woman vs a 200 lb women. One of the studies I read seemed to suggest weight as a factor in Anastrozole side affects.

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This is such a great point! There seems to be only one dose regardless of size or any other factors.
I believe this is on the drug companies and there isn’t a financial incentive to adjust dosing.
Though my oncologist suggested who would want to be the group with a lower dose?
Can you share more info about the study?
Thank you!

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Profile picture for rosy54 @rosy54

I was on Anastrozole for 6 yrs and off it for 1 year My dr suggested to get off of it because of my memory problems . I’m 68 and finding it hard remembering names and following directions when driving. It’s like more I try to remember my mind goes blank😵‍💫 I’ve been to a neurologist and oncologist about it. I chalked it up to chemo brain but was told this usually happens within 1st yr and gradually eases up I now feel I’m getting dementia from it my family sometimes upset me when they say “ we just told you that” or “don’t you remember you just asked me that” It scares me more when I try to remember something I know it’s common knowledge for me and I can’t remember at all😟 I retired year ago because of memory problems so I find myself depressed and anxiety. This Mayo connect site has brought me some relief knowing I’m not alone and not going crazy !
Excellent therapy just knowing others feel same as me and it’s not “ all in our head”. ❤️

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I’m also the same way. I didn’t know it could be because of Asnastrotole. I see my Oncologist next month and talk to her about it. I thought chemo caused it.

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This is my second go round with breast cancer. I took exemestaine the first time now I’m on Anastrozole and I’m losing my words again. Soo I told my family snd friends if I can’t remember a word I will say bucket instead and that way I don’t have to struggle trying to find the right word and they understand I can’t remember. It’s easier on all of us and I don’t get my feeling hurt.

REPLY
Profile picture for rosy54 @rosy54

I was on Anastrozole for 6 yrs and off it for 1 year My dr suggested to get off of it because of my memory problems . I’m 68 and finding it hard remembering names and following directions when driving. It’s like more I try to remember my mind goes blank😵‍💫 I’ve been to a neurologist and oncologist about it. I chalked it up to chemo brain but was told this usually happens within 1st yr and gradually eases up I now feel I’m getting dementia from it my family sometimes upset me when they say “ we just told you that” or “don’t you remember you just asked me that” It scares me more when I try to remember something I know it’s common knowledge for me and I can’t remember at all😟 I retired year ago because of memory problems so I find myself depressed and anxiety. This Mayo connect site has brought me some relief knowing I’m not alone and not going crazy !
Excellent therapy just knowing others feel same as me and it’s not “ all in our head”. ❤️

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So sorry you are experiencing the memory issue. Age itself is a challenge with this but I think Anastrozole is also a factor. I am 79 and in my second year with taking it.

In respect to people reminding you that they already told you something. What the heck!!! I decided i had enough on my plate without that kind of crap. I saw a friend endure this kind of thoughtlessness when another friend tried to respond. I wanted to scream at them. I told her to ask whoever challenges her to just say - I wanted to make sure you remember what you said. People who do this are usually friends or family. You deal with these occurrences as best you can but there is no reason for a person to wear a ‘scarlet letter’! Don’t be a victim. You have obviously noticed this setback which is a very important consciousness. You can challenge yourself and stimulate you brain in many ways.

I would say you are a very savvy person. Don’t fall into the trap of doubting yourself. Don’t be a victim. There is so much about you that deserves recognition. Start giving a greater value to that rather those in your life who have a problem repeating
themselves. 😂

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I am curious if weight influences Anastrozole side effects. The standard dose of 1 mg might work differently for a 150 lb woman vs a 200 lb women. One of the studies I read seemed to suggest weight as a factor in Anastrozole side affects.

REPLY
Profile picture for eku @eku

A question I have is, I personally know many women in academia, research, teaching, management positions who are well beyond their menopausal age and doing a wonderful job. So, if cognitive decline is due to the lack of estrogen, how are we going to explain these brilliant women? If it is due to the estrogen blocking medication, then can we say that there's a difference between the cognitive decline due to menopause vs cognitive decline due to the estrogen blockers?

Jump to this post

I would give this comment 10 "likes" if I could.

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Profile picture for rosy54 @rosy54

I was on Anastrozole for 6 yrs and off it for 1 year My dr suggested to get off of it because of my memory problems . I’m 68 and finding it hard remembering names and following directions when driving. It’s like more I try to remember my mind goes blank😵‍💫 I’ve been to a neurologist and oncologist about it. I chalked it up to chemo brain but was told this usually happens within 1st yr and gradually eases up I now feel I’m getting dementia from it my family sometimes upset me when they say “ we just told you that” or “don’t you remember you just asked me that” It scares me more when I try to remember something I know it’s common knowledge for me and I can’t remember at all😟 I retired year ago because of memory problems so I find myself depressed and anxiety. This Mayo connect site has brought me some relief knowing I’m not alone and not going crazy !
Excellent therapy just knowing others feel same as me and it’s not “ all in our head”. ❤️

Jump to this post

Hang in there! Estrogen blockers are just about as bad as cancer itself! Except they don’t kill you…

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