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AML (Leukemia) diagnosis after Car T therapy
I received Car T therapy for Non Hodgkins Lymphoma in 2018. The therapy was very successful with the complete eradication of the disease. Recently I have been diagnosed with AML (Luekemia). I was advised the likely reason of this unfortunate diagnosis, is the bone marrow has been damaged by the high doses of Chemo Drugs I was administered, prior to becoming eligible to receive the Car T treatment.
I would appreciate hearing from anyone who may had a similar.
experience.
If you are familiar with this, how was the AML treated?
I appreciate any insight you may be able to share.
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@grandpabob! I’m so sorry to hear about the change in your health. You and I met in Connect about the time I was one year out from my AML/bone marrow transplant, 4 years ago. You were fairly new into your Car T transplant!
I’m more than happy to talk to you about this new ‘bump in the road’ you’re facing.
Treatment will depend on what your is doctor is finding as the cause. They will most likely run some genetic testing to see if you have an acquired mutation that is causing the changes in cell production. That will dictate treatment.
I had the standard induction chemo and consolidation chemo for AML which brought me to remission. After that, I did have an Allogenic (donor cells) bone marrow transplant, which is what you’ll be having. Since I had my adventure 5 years ago, there have been newer AML treatments introduced, so maybe that portion has changed. But the transplant will be similar to what you had with Cart T. I’m more than happy to walk you through whatever you need! I’ll be following along with you! Hugs, Lori.
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3 Reactions@colleenyoung, quite a surprise for sure. I will find out the type of therapy that will be used in the next couple of days. The end goal is transplant, remission is the first goal.
Thank you for the questions.
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2 Reactions@grandpabob, this must've been quite a shock to learn of this new diagnosis. I added your question to the Blood Cancers support group as well. I'm tagging fellow members @timt347 @loribmt @edb1123 @lindagi on this discussion. While they don't have your exact story of non-Hodgkin's lymphoma and CAR-T cell therapy, they each have had different treatments for AML.
As I'm sure you've already researched, AML treatment may include chemotherapy, targeted therapy (including monoclonal antibody therapy) or allogeneic stem cell transplantation.
Has your team suggested which treatment might be recommended for you? Is transplant an option given the bone marrow damage?