alendronate and no progress

Posted by hillclan @hillclan, Jun 27, 2025

I have been taking alendronate (Fosamax generic) for 2 years. Just had another DEXA scan, and it showed slightly worse bone strength, by T score. My nurse practitioner thinks I should continue with the alendronate despite this. I have been diligent with calcium intake and vitamin D. Has anyone else had a similar experience?

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Profile picture for njx58 @njx58

No. Water generally helps with absorption.

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My endocrinologist thinks so. At first I was drinking about 20 ounces of water when I took my fosamax and my results were not very good. After that she insisted that i drink only 8 ounces of water with my pill 6 months later I had the blood work repeated and had the results she expected. I guess sportiness more isn't better!

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Profile picture for jbones @jbones

Amen. My PCP could not understand why I was so concerned about my osteoporosis diagnosis. Her words were "why are you so concerned? Everybody is going to get it".

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Not a supportive response to a patient.

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Profile picture for patwerthman @patwerthman

How is Evenity going?

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@patwerthman I have had 3 injections and the second 2 went ok. I am concerned b/c from my reading, the endo should have my P1NP checked but she says it is unnecessary.

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Profile picture for maggieb892 @maggieb892

My endocrinologist thinks so. At first I was drinking about 20 ounces of water when I took my fosamax and my results were not very good. After that she insisted that i drink only 8 ounces of water with my pill 6 months later I had the blood work repeated and had the results she expected. I guess sportiness more isn't better!

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Oh my gosh. Really? This is something I didn’t know either

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Profile picture for aspirecreative @aspirecreative

@patwerthman I have had 3 injections and the second 2 went ok. I am concerned b/c from my reading, the endo should have my P1NP checked but she says it is unnecessary.

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So should a test be called P1NP? Good to learn yours are going ok.

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@hillclan When taking your meds, are you using tap water? If you have used mineral or spring water, it has added calcium which will reduce the drug’s effectiveness.

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Profile picture for aspirecreative @aspirecreative

@patwerthman I have had 3 injections and the second 2 went ok. I am concerned b/c from my reading, the endo should have my P1NP checked but she says it is unnecessary.

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There are a lot of endo’s that don’t follow the bone markers. Personally I don’t understand that point of view. Yes, she should have done your CTX and P1NP. It would tell how much the osteoclast resorption is (CTX) and then the P1NP would show bone-formation marker of the osteoblastic activity. These markers are done prior to starting and then 3-4 months after to see if Evenity makes a difference for you. I would insist on having this done.

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Profile picture for susanew @susanew

@hillclan When taking your meds, are you using tap water? If you have used mineral or spring water, it has added calcium which will reduce the drug’s effectiveness.

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I only use tap water, but thanks for bringing this up because it may help others.

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