Aggressive prostate cancer suppression

Posted by johndavis60 @johndavis60, Feb 6 5:02pm

For those who have aggressive prostate cancer that is controlled by Hormone therapy ( I am on Firmagon and abiraterone) and psa is undetectable, when the cancer comes back, is it always as aggressive (or more aggressive) than before the hormone therapy? Or can it lose some aggressiveness?

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I’ve been taking hormone therapy for eight years. 2.5 years after ADT started I became castrate resistan and I was put on Biclutamide followed by Zytiga About a year later. I was on Zytiga for 2 1/2 years and now I’m on Nubeqa And my PSA has been undetectable for the last 27 months on Nubeqa. 16 years total with PC. Zytiga was never able to keep my PSA undetectable For more than a month, and three years ago I had to have a metastasis zapped on my spine.

I have BRCA2, a genetic problem that makes my cancer more aggressive, but the drugs have kept it from spreading and growing other than the one metastasis.

It’s hard to say what will happen to any one person. I know people that are Gleason nine that have been kept under control for many years, Others have had it come back, but with the drugs we have today prostate cancer is seldom a fatal disease. It’s more like a chronic disease. New treatments have been coming out regularly, So there’s a good chance we will live for decades.

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I don't think it's good to compare your cancer to other's. We each have unique cancer because we each have unique DNA. I belong to another advanced prostate cancer forum and many guys with seemingly less aggressive (G7) are far more advanced than me. I was initially dx'd G9(4+5) GG5 but later after a consult at MSKNY, the prostate pathologist there released a pathology report the Said I was G8(4+4) GG4 but also called out extensive IDC-P and cribiform patterns. In the end it doesn't matter...the cancer will do what the cancer will do.

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