ADT Holiday

Posted by glabelle @glabelle, 6 days ago

For those of you who have been on an initial round of ADT for 6, 12 or 18 months (or whatever time period), and have then taken a break, how long were you able to stay off ADT before your PSA rose to the point where you had to resume ADT? I am Stage IV oligometastatic and my oncologist wants me to take a break from ADT after six months. Have also been through SBRT. Thank you in advance!

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jeff Marchi | @jeffmarc | 2 days ago

In reply to @ajgiant "When he is on a holiday, is he off ALL meds or just the ADT?" + (show)

There are a lot of people that have stopped taking ADT and are taking one of the lutamides By itself. They have the ability to suppress testosterone, so unless it’s really high, they can work quite well.

I know a lot of people on Darolutamide (Nubeqa) alone, including me. Others are on Xtandi, Zytiga and Erleada alone.

glabelle | @glabelle | 2 days ago

In reply to @jeffmarc "There are a lot of people that have stopped taking ADT and are taking one of..." + (show)

Thanks for the helpful info Jeff. I’m a little confused. I am currently taking Nubeqa with Orgovyx. Could you be more specific about how Nubeqa works alone and how the side effects differ from Orgovyx & Nubeqa together. Thanks in advance!

jeff Marchi | @jeffmarc | 2 days ago

Most of the side effects you’re having are coming from Orgovyx. It reduces the testosterone to below 20 which causes numerous problems. These are the common problems.
Hot flashes
Fatigue
Muscle deterioration
Bone weakening
Brain fog
Depression
Weight gain
Difficulty in breathing

Nubeqa alone does not reduce testosterone, it reduces the ability of testosterone to work to feed the cancer. If enough time has gone by for your testosterone to come back after having used Orgovyx, then most of these side effects mentioned above do not continue to occur.