Adding d-Mannose, stage 3 CRC adenocarcinoma, FOLFOX chemo

D-Mannose, as you probably know is a sugar closely related to glucose It is found in high concentrations in fruits such as cranberries. It is sold as a supplement since many people think it helps with UTIs by interfering with the growth of e coli. There are some recent studies and especially a January 2024 study done in China which Indicate oral administration of D-mannose dramatically inhibited angiogenesis and tumor growth in mice. Their findings reveal a previously unrecognized anti-tumor mechanism of D-mannose by destabilizing VEGFR2. This is a growth factor which cancers use to spread by creating new blood vessels. However these studies were only done in cell culture and in mice, I have not been able to find any published human studies. Taking this as a supplement probably won't hurt. The problem is you don't know the maximum amount you could take without it being a safety issue. Suggest you talk to your oncologist and ask the maximum amount of supplement can recommend

Hello @missycanary and welcome to Mayo Connect. We have had numerous Connect members discuss d-Monnose. Here is a link to many of those discussions. https://connect.mayoclinic.org/search/?search=d-Mannose

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I also found an article on this product on the WebMD website. Here is a link to more information,
https://www.webmd.com/vitamins-and-supplements/d-mannose-uses-and-risks

Has your husband's oncologist recommended this to help prevent the UTIs?

I’m thinking it would be good, having had good results myself. We’re asking for use confirmation from them & also the oncology dietician. They are hesitant to confirm no interference with chemo, just not enough info, as they consider it to be a supplement.