Adding a second medicine question

10 ng/dL

The -lutamides (Apalutamide, Enzalutamide, and Darolutamide) are newer than Abiraterone and don't require a steroid, if you want to ask your oncologist about them. I've been on ADT + Apalutamide for nearly 4 years, and the combination has been highly effective for me (your mileage may vary).

FWIW, I was started on Orgovyx based on biopsy results (Geason 9 - 5+4) and it was started immediately following a PSMA PET scan. Nubequa was added immediately after the PET results showed metastatic lymph and bone involvement 4 days later. I'm new at this fight and just a layman, but I would think that unless testosterone is a confirmed zero, ARI added to ADT is prudent, especially if the disease has spread beyond the prostate.

Here are some of the other AR inhibitors and their safety profiles. The source of the information is at the bottom of the chart so that you can search further.

What you describe is standard of care. You Probably will have no problem at all with Darolutamide. The other lutamides Have more side effects.

Something like Darolutamide Can control your PSA better than Orgovyx.

You don’t tell us anything about your case, Your results like your PSA your Gleason score what treatment you’ve had and What is going on that your doctor wanted to add the second drug? If you are already metastatic than that, explains it.

I've had removal+radiation+ADT. I've been on Orgovyx only for 28 months; 24 months post pelvic radiation. My Drs have never mentioned a second combo medicine. I was stage 4a and G9. My PSA has ben < 0.01 since radiation. I've had no major side effects to Orgovyx that I'm aware of. I do have muscle and joint soreness, and overall tiredness. My Drs want me to go off ADT.

What ADT are you on?

After all this time, if your PSA has remained < .01 For over a year, stopping ADT really makes sense.

You can get blood test every month for three months(or longer) to see if the PSA starts rising, Then every three months if still low and eventually every six months.. Close to 70% of people with PC are cured or at least go into long-term remission.

I know a lot of doctors would recommend that, you could get another opinion.

I attend weekly advanced prostate cancer meetings with Ancan.org. We had somebody come in to a meeting recently who had his PSA start to rise 30 years after he had surgery, He was a Gleeson nine also. We actually get a lot of people in who are Gleason nine and their PSA starts to rise after many years off drugs.

Initially Firmagon, the Orgovyx for the past 15 months or so once it became widely available in Canada (drug makers often focus on getting approvals for big markets like the U.S. and E.U. first, the circle back around to the middle-sized ones).

I had Gleason 8 on 2 of 12 biopsy samples characterized high risk, 1 Gleason 7, 1 Gleason 6, and 2 pelvic lymph nodes positive on PSMA PET scan. Am characterized as T1N1M0. I have been on Orgovyx since March 30th and briefly had abiraterone, my psa dropped from 30 on March 25th to .46 on June 5th. Will get radiation starting mid July.