I had a baseline bone marrow biopsy 8 years ago, at the onset of MGUS. My deranged plasma cells were at 5% (a peer-reviewed paper I read referred to the precancerous cells as deranged. I like that better). If your K/L ratio is within range (between 0.26 and 1.65) then that is reason to celebrate. Mine is 11, still OK but been ramping up for a few years. Your GFR (kidney filtration rate) and some other numbers are tied more to kidney function. My kidney function bloodwork didn't decrease until my MGUS progressed, and in my case is mostly due to meds, not MGUS. My red and white blood cells have been low for many years and are probably genetic (celiac). If you are on meds then it would be good to see if any of them have kidney or other side effects, or interfere with each other (pharmacist, doctors aren't good at this). I am a 69 yo woman and try to slow my MGUS with diet, exercise, avoiding stress, and dark chocolate (just because I'm a chocoholic).