It was FDA approved in 1997 as Agrylin....not generic Anagrelide until 2005 or so. It was new when my very high platelet count was noted, re-directing me to oncology hemotologist. He suggested the new drug, see if it worked, without even a bone marrow biopsy. It worked, and worked until he retired, a new doctor within my care providers started his Frankenstein work on me. Happy to have self-advocated for a switch after 3-4 horrible months with hydroxyurea. That was probably around 2010.