My platelets were over 1800 when first found in thorough, routine exam over 20 years ago when Agrlin (anagrelide) was fairly new. Don't know about JAK 2 tho that drug has done the trick, lowering platelets below 400 without impacting other blood results. Recently asked my hematolgist about why it isn't more widely prescribed for ET....he said pethaps habit, if it works why switch...