I am not a medical professional.

Here's a summary by Mayo - https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/hdl-cholesterol/art-20046388#:~:text=Higher%20levels%20of%20HDL%20cholesterol,your%20bloodstream%20attached%20to%20proteins.

And, an excerpt from that link.
"Oddly enough, people who naturally have extremely high HDL levels — above 100 mg/dL (2.5mmol/L) — appear to be at higher risk of heart disease. This may be caused by genetic factors."