When I first started taking HU I had taken it 500 MG 9 days in a row. It brought my platelets down to the normal range but I felt awful. I had so much fatigue and bone pain. They then started me on the 500 MG 3 times per week MWF. I am ok with that dosage. I will have a tired day once in a while and bones aching/hurting especially my shins. My platelets are creeping back up so he may change my dosage . I have lost some hair but not bad, It is NOT coming out by the handfuls. My Dr said that was not one of the side effects. I told him it may not be but mine was not coming out before HU. I was diagnosed in August of 23. I have requested a second opinion with the Mayo Clinic. Praying for the best for you!!