I have Essential Thrombocythemia. Started with 3 pills weekly of hydroxyurea, and now at once a day as my platelets were not going down enough. I was told to take in the am with my other meds and vitamins. Gave me diarrhea. I decided on my own to take hydroxyurea in the evening after dinner. Fewer tummy problems. Other than softer stools, not much of an adjustment. I have started to have very vivid dreams, often pretty weird ones, that linger and stay with me after waking. But nothing really frightening. Other than that, so far so good.