Finding a balance between medications and their side effects can sure be challenging. I’m sorry to hear you’re so fatigued with taking Hydroxurea at the recommended dosage. I know right now you don’t have a choice because of the upcoming surgery. Your surgeon doesn’t want you to experience any blood clotting so it’s important to get your platelet level down to a healthy limit.
After surgery and recovery, maybe you can speak with your hematologist about adjusting your dosage to a different schedule? I know some members have mentioned their doctors have allowed them do something like alternate 1 pill per day/2 pills per day. Or 1 pill daily but twice per week they add the extra pill. It can minimize the side effects but also maintain a healthy platelet level.
In the meantime I hope your numbers get to a happy spot so that you can go ahead with your surgery! Do you have a target date for surgery?