You can get face mask liners to deal with the irritation. I have no further info on that, sorry, but it is discussed at apneaboard.com forums. Also, a really good non-steroidal cream is Barriere Cream....that spelling. At drug stores.

I'm afraid there is simply no substitute for trying a range of mask, different materials and configurations, different manufacturers. It's a pain, and could get costly, but at some point you might find that you do well with a couple and should probably get into the habit of swapping them to prevent either one from 'getting old' on you or if each eventually causes its own problems.