I am taking 500 mg Hydrea on MWF. Still a little high but hematologist doesn't seem to be concerned. On one of my visits I saw the PA. She advised me to contact the Leukemia & Lymphoma Society. They sent me a lot of info and most of it did not pertain to me but what did was helpful. I have Essential Thrombocythemia its a lot to understand and believe me I am no where close to understanding it all. Wishing your wife the best.