Yes. I’ve had fibromyalgia for over 10 years which had progressively gotten severe enough that every third day or so the usual pain, fatigue etc. built up to the point I couldn’t get out of bed let alone exercise as they recommend and as I used to do. Nothing my Gen Practice doctor tried seemed to work for long, and they resorted to suggesting mental health visits and antidepressants. I’ve been fortunate enough to have a spouse with a decent enough income that although difficult, I have had the luxury of time for mindfulness and meditation, etc. which has helped. But it was not until I saw a holistic nurse practitioner at my clinic that I was prescribed low dose Naltrexone to aid with the pain and inflammation. It seemed to reduce pain enough initially that I was able to exercise and had excess energy. However, my MD started messing with my thyroid hormone replacement dose when my insurance company quit allowing me the brand I had taken for years, and now my pain has returned mostly, and will probably remain until my dose is adequate.