I totally agree, I myself just started on Hydroxyurea , first, it was every day, but my platelets went way up, so now we are trying three times a week, and will go in for another blood test to see how that’s going. I have no side effects from this drug and feel lucky for that. The way I look at it is, its like a recipe, sometimes you have to add and subtract things to find out what works for your body. I am also Jak 2. You need to inform yourself and write down all your questions for your doctor, and always get a second opinion.