I have done 11 months of Evenity and not experienced any negative side effects. In Canada, you have to learn to do the injections yourself or get someone else to give them to you and only on your stomach as the prescribed site. My hubby learned very quickly and once I learned to get the shots in my stomach while sitting [not standing or lying down] and "pinching an inch" of fat, the pain was quite minimal and after 30 minutes, I had totally forgotten that I'd even had the shots.