@cuyler, I think you're asking, can chemotherapy makes my wife's cognitive impairment worse? Or are you also concerned about how a person with dementia will manage treatment like chemotherapy?

These are both really good questions to discuss with your wife's oncologist. Some chemotherapy drugs are more likely to cause brain fog than others, not every chemo drug does. What chemo drug is being recommended for her?

Is your wife worried about getting treatment? Or confused and anxious about getting IV chemo? Or is her chemo regimen oral?