I have just started Kevzara along with the methotrexate. It is a biologic which targets Il- 6. I had my first shot almost two weeks ago. Blood work drawn this past week revealed some fairly startling news. My inflammation numbers, both sed and reactive protein are now normal after a year of pmr. Even on 30mg then 20 to 10mg of prednisone over the past year the inflammation numbers had remained high. So I am so hopeful now that something will help me with the below 10mg taper.