@pb50. Pam, I figure it could be worth a try. Estradiol, by the way, isn’t considered HRT. The estrogen is “unopposed” by progesterone which could be considered a contraindication however the gynecologists I have talked with tell me that very little estrogen is absorbed by the blood stream since Estradiol is applied transdermally (to the skin). It’s a good question to ask the provider who prescribed your Estradiol. Still, why not try a non-estrogen product and see if you like the results.